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    mraZ DNA-binding transcriptional repressor MraZ [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944810, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mraZ
    Official Full Name
    DNA-binding transcriptional repressor MraZ
    Primary source
    ECOCYC:EG11084
    Locus tag
    b0081
    See related
    ASAP:ABE-0000302
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0082; yabB
    Summary
    The MraZ protein is highly conserved in bacteria, but its function has not yet been determined. [More information is available at EcoCyc: EG11084].
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    Genomic context

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    Sequence:
    NC_000913.3 (89634..90092)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene acetolactate synthase/acetohydroxybutanoate synthase, regulatory subunit Neighboring gene DNA-binding transcriptional dual regulator Cra Neighboring gene 16S rRNA m(4)C1402 methyltransferase Neighboring gene cell division protein FtsL Neighboring gene peptidoglycan DD-transpeptidase FtsI Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MraZ from Escherichia coli: cloning, purification, crystallization and preliminary X-ray analysis. Adams MA, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2005 Apr 1. PMID 16511046, Free PMC Article
    2. Escherichia coli Proteome Microarrays Identified the Substrates of ClpYQ Protease. Tsai CH, et al. Mol Cell Proteomics, 2017 Jan. PMID 27864322, Free PMC Article
    3. AbrB-like transcription factors assume a swapped hairpin fold that is evolutionarily related to double-psi beta barrels. Coles M, et al. Structure, 2005 Jun. PMID 15939023
    4. Nucleotide sequence of the regulatory region of the gene pbpB of Escherichia coli. Gómez MJ, et al. Nucleic Acids Res, 1990 May 11. PMID 2187182, Free PMC Article
    5. Proteomics of Mycoplasma genitalium: identification and characterization of unannotated and atypical proteins in a small model genome. Balasubramanian S, et al. Nucleic Acids Res, 2000 Aug 15. PMID 10931922, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results provide evidence that YbaB is a novel substrate of ClpYQ protease through its binding to ClpY subunit.
      Title: Escherichia coli Proteome Microarrays Identified the Substrates of ClpYQ Protease.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription initiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoid IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional repressor MraZ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      89634..90092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414623.1 DNA-binding transcriptional repressor MraZ [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414623.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1MMA9
      Conserved Domains (1) summary
      TIGR00242
      Location:1 → 151
      TIGR00242; division/cell wall cluster transcriptional repressor MraZ
    Nucleotide Protein
    Heading Accession and Version

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    Other Literature Sources
    Molecular Biology Databases
    Research Materials