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    secD Sec translocon accessory complex subunit SecD [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949133, updated on 3-Dec-2024

    Summary

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    Official Symbol
    secD
    Official Full Name
    Sec translocon accessory complex subunit SecD
    Primary source
    ECOCYC:EG10938
    Locus tag
    b0408
    See related
    ASAP:ABE-0001417
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0402
    Summary
    SecYEG complex interacts with SecDFyajC to form a hexameric holocomplex. [More information is available at EcoGene: EG10938]. SecD is a membrane component of the SecD/SecF/YajC/YidC complex, which is itself a subclass of the Sec protein secretion complex. [More information is available at EcoCyc: EG10938].
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    Genomic context

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    Sequence:
    NC_000913.3 (427647..429494)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-guanine transglycosylase Neighboring gene Sec translocon accessory complex subunit YajC Neighboring gene Sec translocon accessory complex subunit SecF Neighboring gene HNH nuclease family protein YajD

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overproduction, purification and characterization of SecD and SecF, integral membrane components of the protein translocation machinery of Escherichia coli. Matsuyama S, et al. Biochim Biophys Acta, 1992 Jul 13. PMID 1633199
    2. Functional complementation of E. coli secD and secG mutants by Helicobacter pylori homologues. Fitchen N, et al. FEMS Microbiol Lett, 2003 Dec 5. PMID 14659543
    3. The secD locus of E. coli codes for two membrane proteins required for protein export. Gardel C, et al. EMBO J, 1990 Dec. PMID 2249673, Free PMC Article
    4. Export of the outer membrane lipoprotein is defective in secD, secE, and secF mutants of Escherichia coli. Sugai M, et al. J Bacteriol, 1992 Apr. PMID 1556071, Free PMC Article
    5. SecDFyajC is not required for the maintenance of the proton motive force. Nouwen N, et al. FEBS Lett, 2001 Nov 9. PMID 11707277

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. two mutations confer cold-sensitive phenotype by inactivating the SecDF-YajC complex in protein translocation
      Title: Inactivation of protein translocation by cold-sensitive mutations in the yajC-secDF operon.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-transporting ATPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein insertion into membrane from inner side IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein targeting IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport by the Sec complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein transport by the Sec complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cell envelope Sec protein transport complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sec translocon accessory complex subunit SecD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      427647..429494
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414942.1 Sec translocon accessory complex subunit SecD [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414942.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7CM75, A0A8S7NSZ0
      Conserved Domains (2) summary
      PRK05812
      Location:8 → 615
      secD; preprotein translocase subunit SecD; Reviewed
      pfam13721
      Location:2 → 103
      SecD-TM1; SecD export protein N-terminal TM region
    Nucleotide Protein
    Heading Accession and Version

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