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    ytfE iron-sulfur cluster repair protein YtfE [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948724, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ytfE
    Official Full Name
    iron-sulfur cluster repair protein YtfE
    Primary source
    ECOCYC:G7866
    Locus tag
    b4209
    See related
    ASAP:ABE-0013766
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    dnrN; ECK4205
    Summary
    ytfE is induced by NO as part of the NsrR regulon. [More information is available at EcoGene: EG12505]. The YtfE protein appears to be involved in the repair of damaged iron-sulfur clusters . [More information is available at EcoCyc: G7866].
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    Genomic context

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    Sequence:
    NC_000913.3 (4431321..4431983, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene peptidyl-prolyl cis-trans isomerase FklB Neighboring gene D-serine/alanine/glycine/:H(+)symporter Neighboring gene inner membrane protein YtfF Neighboring gene NAD(P)H:quinone oxidoreductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Di-iron RIC Protein (YtfE) of Escherichia coli Interacts with the DNA-Binding Protein from Starved Cells (Dps) To Diminish RIC Protein-Mediated Redox Stress. Silva LSO, et al. J Bacteriol, 2018 Dec 15. PMID 30249704, Free PMC Article
    2. Escherichia coli RIC is able to donate iron to iron-sulfur clusters. Nobre LS, et al. PLoS One, 2014. PMID 24740378, Free PMC Article
    3. Detection by whole genome microarrays of a spontaneous 126-gene deletion during construction of a ytfE mutant: confirmation that a ytfE mutation results in loss of repair of iron-sulfur centres in proteins damaged by oxidative or nitrosative stress. Vine CE, et al. J Microbiol Methods, 2010 Apr. PMID 20138195
    4. Iron-sulfur repair YtfE protein from Escherichia coli: structural characterization of the di-iron center. Todorovic S, et al. J Biol Inorg Chem, 2008 Jun. PMID 18357473
    5. Escherichia coli YtfE is a di-iron protein with an important function in assembly of iron-sulphur clusters. Justino MC, et al. FEMS Microbiol Lett, 2006 Apr. PMID 16553864

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Escherichia coli strains defective in iron-sulfur cluster repair protein (YtfE) that lack the high-affinity nitric oxide (NO) reductase activity of the hybrid cluster protein (Hcp) are less sensitive to nitrosative stress than isogenic ytfE(+) strains. The role for YtfE is to reverse nitrosative damage by releasing NO from nitrosylated proteins into the cytoplasm for the high-affinity NO reductase activity of Hcp.
      Title: Release of nitric oxide by the Escherichia coli YtfE (RIC) protein and its reduction by the hybrid cluster protein in an integrated pathway to minimize cytoplasmic nitrosative stress.
    2. Escherichia coli RIC is able to donate iron to iron-sulfur clusters.
      Title: Escherichia coli RIC is able to donate iron to iron-sulfur clusters.
    3. The authors confirm that YtfE is required to repair damage to iron-sulfur centres and for hydrogen peroxide resistance.
      Title: Detection by whole genome microarrays of a spontaneous 126-gene deletion during construction of a ytfE mutant: confirmation that a ytfE mutation results in loss of repair of iron-sulfur centres in proteins damaged by oxidative or nitrosative stress.
    4. YidZ and YtfE protect anaerobically grown Escherichia coli against nitric oxide
      Title: New genes implicated in the protection of anaerobically grown Escherichia coli against nitric oxide.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables iron ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nitrite reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to nitrosative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    iron-sulfur cluster repair protein YtfE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4431321..4431983 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418630.1 iron-sulfur cluster repair protein YtfE [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418630.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAE9PZF1
      Conserved Domains (1) summary
      PRK10992
      Location:1 → 220
      PRK10992; iron-sulfur cluster repair protein YtfE
    Nucleotide Protein
    Heading Accession and Version

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