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    phoP DNA-binding transcriptional dual regulator PhoP [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945697, updated on 3-Dec-2024

    Summary

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    Official Symbol
    phoP
    Official Full Name
    DNA-binding transcriptional dual regulator PhoP
    Primary source
    ECOCYC:EG10731
    Locus tag
    b1130
    See related
    ASAP:ABE-0003807
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1116
    Summary
    PhoPQ has been primarily characterized in Salmonella, with significant differences from Escherichia coli. [More information is available at EcoGene: EG10731]. Transcriptional regulatory protein PhoP is a member of the two-component regulatory system PhoQ/PhoP. [More information is available at EcoCyc: EG10731].
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    Genomic context

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    Sequence:
    NC_000913.3 (1189776..1190447, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene peptidase T Neighboring gene 50S ribosomal protein L16-arginine 3-hydroxylase Neighboring gene sensor histidine kinase PhoQ Neighboring gene adenylosuccinate lyase Neighboring gene lysogenization regulator

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structures of the receiver domain of the response regulator PhoP from Escherichia coli in the absence and presence of the phosphoryl analog beryllofluoride. Bachhawat P, et al. J Bacteriol, 2007 Aug. PMID 17545283, Free PMC Article
    2. Molecular genetic analysis of the Escherichia coli phoP locus. Groisman EA, et al. J Bacteriol, 1992 Jan. PMID 1530848, Free PMC Article
    3. Identifying promoter features of co-regulated genes with similar network motifs. Harari O, et al. BMC Bioinformatics, 2009 Apr 29. PMID 19426448, Free PMC Article
    4. Osmosensing by the bacterial PhoQ/PhoP two-component system. Yuan J, et al. Proc Natl Acad Sci U S A, 2017 Dec 12. PMID 29183977, Free PMC Article
    5. The H box-harboring domain is key to the function of the Salmonella enterica PhoQ Mg2+-sensor in the recognition of its partner PhoP. Castelli ME, et al. J Biol Chem, 2003 Jun 27. PMID 12702718

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data suggest that MgrB affects the acid resistance of E. coli by modulating the expression of iraM, but not completely through PhoP/Q.
      Title: MgrB affects the acid stress response of Escherichia coli by modulating the expression of iraM.
    2. findings directly link the PhoQ/PhoP two-component system to bacterial osmosensing
      Title: Osmosensing by the bacterial PhoQ/PhoP two-component system.
    3. Both MicA and GcvB bind phoPQ mRNA in vivo and in vitro around the translation initiation region of phoP. Binding of either small RNA is sufficient to inhibit ribosome binding and induce mRNA degradation
      Title: Post-transcriptional control of the Escherichia coli PhoQ-PhoP two-component system by multiple sRNAs involves a novel pairing region of GcvB.
    4. Taken together, these results demonstrate that a decrease in the oxidizing activity of the periplasm stimulates PhoQ/PhoP and may reveal a new input stimulus for this important two-component system.
      Title: Perturbation of the oxidizing environment of the periplasm stimulates the PhoQ/PhoP system in Escherichia coli.
    5. MicA directly pairs with phoPQ mRNA in the translation initiation region of phoP and presumably inhibits translation by competing with ribosome binding.
      Title: MicA sRNA links the PhoP regulon to cell envelope stress.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphorelay response regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-DNA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-DNA complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator PhoP

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1189776..1190447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415648.1 DNA-binding transcriptional dual regulator PhoP [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415648.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5C9AP00, A0A6N8QQX4
      Conserved Domains (1) summary
      PRK10816
      Location:1 → 223
      PRK10816; two-component system response regulator PhoP
    Nucleotide Protein
    Heading Accession and Version

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