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    lgt phosphatidylglycerol--prolipoprotein diacylglyceryl transferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947303, updated on 17-Dec-2024

    Summary

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    Official Symbol
    lgt
    Official Full Name
    phosphatidylglycerol--prolipoprotein diacylglyceryl transferase
    Primary source
    ECOCYC:EG12128
    Locus tag
    b2828
    See related
    ASAP:ABE-0009270
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2824; umpA
    Summary
    Sequence analysis, mutation, and expression studies show that lgt and the gene immediately downstream, thyA, form an operon . [More information is available at EcoCyc: EG12128].
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    Genomic context

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    Sequence:
    NC_000913.3 (2965162..2966037, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene prepilin-type N-terminal cleavage/methylation domain-containing protein PpdB Neighboring gene prepilin-type N-terminal cleavage/methylation domain-containing protein PpdA Neighboring gene thymidylate synthase Neighboring gene phosphoenolpyruvate-protein phosphotransferase PtsP Neighboring gene RNA pyrophosphohydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and genetic mapping of the structural gene for an essential Escherichia coli membrane protein. Williams MG, et al. J Bacteriol, 1989 Jan. PMID 2644208, Free PMC Article
    2. Localization and characterization of prolipoprotein diacylglyceryl transferase (Lgt) critical in bacterial lipoprotein biosynthesis. Selvan AT, et al. Biochimie, 2008 Nov-Dec. PMID 18602442
    3. Structure-function relationship of bacterial prolipoprotein diacylglyceryl transferase: functionally significant conserved regions. Qi HY, et al. J Bacteriol, 1995 Dec. PMID 7592473, Free PMC Article
    4. A Defect in Lipoprotein Modification by Lgt Leads to Abnormal Morphology and Cell Death in Escherichia coli That Is Independent of Major Lipoprotein Lpp. Legood S, et al. J Bacteriol, 2022 Sep 20. PMID 35938851, Free PMC Article
    5. Roles of histidine-103 and tyrosine-235 in the function of the prolipoprotein diacylglyceryl transferase of Escherichia coli. Sankaran K, et al. J Bacteriol, 1997 May. PMID 9139912, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Defect in Lipoprotein Modification by Lgt Leads to Abnormal Morphology and Cell Death in Escherichia coli That Is Independent of Major Lipoprotein Lpp.
      Title: A Defect in Lipoprotein Modification by Lgt Leads to Abnormal Morphology and Cell Death in Escherichia coli That Is Independent of Major Lipoprotein Lpp.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipoprotein biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipoprotein biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipoprotein biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipoprotein biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylglycerol--prolipoprotein diacylglyceryl transferase
    NP_417305.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2965162..2966037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417305.1 phosphatidylglycerol--prolipoprotein diacylglyceryl transferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417305.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AF40, A0A830V0E2
      Conserved Domains (1) summary
      PRK00052
      Location:5 → 288
      PRK00052; prolipoprotein diacylglyceryl transferase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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