U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    zur DNA-binding transcriptional repressor Zur [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948552, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    zur
    Official Full Name
    DNA-binding transcriptional repressor Zur
    Primary source
    ECOCYC:EG11929
    Locus tag
    b4046
    See related
    ASAP:ABE-0013249
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4038; yjbK; znuR
    Summary
    Although the N-terminal sequence was derived from a vector with an artificial RBS, Patzer and Hantke (2000) demonstrate that the second ATG is the correct start. [More information is available at EcoGene: EG11929].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (4259488..4260003, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA damage-inducible protein F Neighboring gene putative stress response protein YjbJ Neighboring gene uncharacterized protein YjbL Neighboring gene DUF2713 domain-containing protein YjbM

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Biphasic unbinding of a metalloregulator from DNA for transcription (de)repression in Live Bacteria. Jung W, et al. Nucleic Acids Res, 2020 Mar 18. PMID 32009151, Free PMC Article
    2. Bacterial zinc transporters and regulators. Hantke K. Biometals, 2001 Sep-Dec. PMID 11831459
    3. Characterization of the metal receptor sites in Escherichia coli Zur, an ultrasensitive zinc(II) metalloregulatory protein. Outten CE, et al. Biochemistry, 2001 Sep 4. PMID 11523983
    4. Structural and mechanistic basis of zinc regulation across the E. coli Zur regulon. Gilston BA, et al. PLoS Biol, 2014 Nov. PMID 25369000, Free PMC Article
    5. Simulating in vitro transcriptional response of zinc homeostasis system in Escherichia coli. Cui J, et al. BMC Syst Biol, 2008 Oct 24. PMID 18950480, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In live Escherichia coli cells, Zur's unbinding rate from DNA is sensitive to Zur protein concentration in a first-of-its-kind biphasic manner, initially impeded and then facilitated with increasing Zur concentration.
      Title: Biphasic unbinding of a metalloregulator from DNA for transcription (de)repression in Live Bacteria.
    2. pliG is directly regulated by Zur in a zinc responsive manner
      Title: Structural and mechanistic basis of zinc regulation across the E. coli Zur regulon.
    3. N-terminus verified by Edman degradation on complete protein
      Title: The zinc-responsive regulator Zur and its control of the znu gene cluster encoding the ZnuABC zinc uptake system in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of secondary metabolite biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-DNA complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    DNA-binding transcriptional repressor Zur

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4259488..4260003 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418470.4 DNA-binding transcriptional repressor Zur [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418470.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5N8HH94
      Conserved Domains (1) summary
      PRK11639
      Location:1 → 169
      PRK11639; zinc uptake transcriptional repressor Zur
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.