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    eptC phosphoethanolamine transferase EptC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948458, updated on 17-Dec-2024

    Summary

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    Official Symbol
    eptC
    Official Full Name
    phosphoethanolamine transferase EptC
    Primary source
    ECOCYC:EG11914
    Locus tag
    b3955
    See related
    ASAP:ABE-0012947
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3946; yijP
    Summary
    YijP has similarity to YijP of Escherichia coli K1, which is required for that strain to invade brain microvascular endothelial cells and thereby cross the blood-brain barrier . [More information is available at EcoCyc: EG11914].
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    Genomic context

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    Sequence:
    NC_000913.3 (4148532..4150265, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative formate acetyltransferase 2 Neighboring gene putative pyruvate formate-lyase 2 activating enzyme PflC Neighboring gene putative PTS enzyme IIB component FrwD Neighboring gene putative DNA-binding transcriptional regulator YijO Neighboring gene phosphoenolpyruvate carboxylase Neighboring gene acetylornithine deacetylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The gene locus yijP contributes to Escherichia coli K1 invasion of brain microvascular endothelial cells. Wang Y, et al. Infect Immun, 1999 Sep. PMID 10456927, Free PMC Article
    2. Identification of cptA, a PmrA-regulated locus required for phosphoethanolamine modification of the Salmonella enterica serovar typhimurium lipopolysaccharide core. Tamayo R, et al. J Bacteriol, 2005 May. PMID 15866924, Free PMC Article
    3. Phosphoethanolamine substitution in the lipid A of Escherichia coli O157 : H7 and its association with PmrC. Kim SH, et al. Microbiology (Reading), 2006 Mar. PMID 16514146
    4. Molecular and structural basis of inner core lipopolysaccharide alterations in Escherichia coli: incorporation of glucuronic acid and phosphoethanolamine in the heptose region. Klein G, et al. J Biol Chem, 2013 Mar 22. PMID 23372159, Free PMC Article
    5. A phosphoethanolamine transferase specific for the outer 3-deoxy-D-manno-octulosonic acid residue of Escherichia coli lipopolysaccharide. Identification of the eptB gene and Ca2+ hypersensitivity of an eptB deletion mutant. Reynolds CM, et al. J Biol Chem, 2005 Jun 3. PMID 15795227

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables phosphotransferase activity, phosphate group as acceptor EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables phosphotransferase activity, phosphate group as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphotransferase activity, phosphate group as acceptor IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity, transferring phosphorus-containing groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide core region biosynthetic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in lipopolysaccharide core region biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipopolysaccharide core region biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide core region biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphoethanolamine transferase EptC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4148532..4150265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418390.1 phosphoethanolamine transferase EptC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418390.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T6A0C2
      Conserved Domains (1) summary
      NF012179
      Location:13 → 568
      CptA; phosphoethanolamine transferase CptA
    Nucleotide Protein
    Heading Accession and Version

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