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    moaE molybdopterin synthase catalytic subunit [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945399, updated on 3-Dec-2024

    Summary

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    Official Symbol
    moaE
    Official Full Name
    molybdopterin synthase catalytic subunit
    Primary source
    ECOCYC:EG11598
    Locus tag
    b0785
    See related
    ASAP:ABE-0002678
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    chlA5; ECK0774
    Summary
    Molybdopterin synthase catalyzes the second segment of the pathway leading to the synthesis of the molybdenum cofactor, molybdopterin guanine dinucleotide, which chelates molybdate and is present in and essential for the activity of all Escherichia coli's molybdenum-containing enzymes. [More information is available at EcoCyc: EG11598].
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    Genomic context

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    Sequence:
    NC_000913.3 (819295..819747)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein MoaB Neighboring gene cyclic pyranopterin monophosphate synthase Neighboring gene molybdopterin synthase sulfur carrier subunit Neighboring gene Bax1-I family protein YbhL Neighboring gene Bax1-I family protein YbhM

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency. Daniels JN, et al. Biochemistry, 2008 Jan 15. PMID 18092812
    2. Crystal structure of molybdopterin synthase and its evolutionary relationship to ubiquitin activation. Rudolph MJ, et al. Nat Struct Biol, 2001 Jan. PMID 11135669
    3. Thermodynamic analysis of subunit interactions in Escherichia coli molybdopterin synthase. Tong Y, et al. Biochemistry, 2005 Feb 22. PMID 15709772
    4. Thiocarboxylation of molybdopterin synthase provides evidence for the mechanism of dithiolene formation in metal-binding pterins. Gutzke G, et al. J Biol Chem, 2001 Sep 28. PMID 11459846
    5. Structural studies of molybdopterin synthase provide insights into its catalytic mechanism. Rudolph MJ, et al. J Biol Chem, 2003 Apr 18. PMID 12571227

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: The biosynthesis of molybdopterin in Escherichia coli. Purification and characterization of the converting factor.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables molybdopterin synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Mo-molybdopterin cofactor biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Mo-molybdopterin cofactor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in molybdopterin cofactor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of molybdopterin synthase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    molybdopterin synthase catalytic subunit
    NP_415306.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      819295..819747
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415306.1 molybdopterin synthase catalytic subunit [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415306.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7D7PK28
      Conserved Domains (1) summary
      PRK10678
      Location:1 → 150
      moaE; molybdopterin synthase catalytic subunit MoaE
    Nucleotide Protein
    Heading Accession and Version

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