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    appA periplasmic phosphoanhydride phosphatase/multiple inositol-polyphosphate phosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946206, updated on 3-Dec-2024

    Summary

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    Official Symbol
    appA
    Official Full Name
    periplasmic phosphoanhydride phosphatase/multiple inositol-polyphosphate phosphatase
    Primary source
    ECOCYC:EG10049
    Locus tag
    b0980
    See related
    ASAP:ABE-0003305
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0971
    Summary
    EvgAS regulon. [More information is available at EcoGene: EG10049].
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    Genomic context

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    Sequence:
    NC_000913.3 (1040617..1041915)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene cytochrome bd-II subunit 2 Neighboring gene cytochrome bd-II accessory subunit AppX Neighboring gene protein-tyrosine kinase Etk Neighboring gene phosphotyrosine-protein phosphatase Etp Neighboring gene putative exopolysaccharide export lipoprotein GfcE

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Assembly of mutations for improving thermostability of Escherichia coli AppA2 phytase. Kim MS, et al. Appl Microbiol Biotechnol, 2008 Jul. PMID 18443782
    2. Unusual pattern of nucleoside polyphosphate hydrolysis by the acid phosphatase (optimum pH = 2.5) of Escherichia coli. Tetu C, et al. Biochem Biophys Res Commun, 1979 Mar 15. PMID 378222
    3. Overexpression, site-directed mutagenesis, and mechanism of Escherichia coli acid phosphatase. Ostanin K, et al. J Biol Chem, 1992 Nov 15. PMID 1429631
    4. Identification of the gene appA for the acid phosphatase (pH optimum 2.5) of Escherichia coli. Dassa E, et al. Mol Gen Genet, 1985. PMID 2993816
    5. Use of TnphoA to detect genes for exported proteins in Escherichia coli: identification of the plasmid-encoded gene for a periplasmic acid phosphatase. Boquet PL, et al. J Bacteriol, 1987 Apr. PMID 3031017, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study elucidated the importance of salt bridges for AppA phytase's thermostability, and proved salt bridges play a key role in E. coli AppA phytase's thermostability.
      Title: Relationship between Escherichia coli AppA phytase's thermostability and salt bridges.
    2. N-terminus verified by Edman degradation on mature peptide
      Title: Characterization and overproduction of the Escherichia coli appA encoded bifunctional enzyme that exhibits both phytase and acid phosphatase activities.
    3. The nonconsecutive disulfide bond of Escherichia coli phytase (AppA) renders it dependent on the protein-disulfide isomerase, DsbC.
      Title: The nonconsecutive disulfide bond of Escherichia coli phytase (AppA) renders it dependent on the protein-disulfide isomerase, DsbC.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4-phytase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acid phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol phosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables membrane scission GTPase motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sugar-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sugar-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sugar-phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to anoxia IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to phosphate starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in outer membrane-bounded periplasmic space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    periplasmic phosphoanhydride phosphatase/multiple inositol-polyphosphate phosphatase
    NP_415500.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1040617..1041915
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415500.1 periplasmic phosphoanhydride phosphatase/multiple inositol-polyphosphate phosphatase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415500.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      Q8GN88, Q8RKD5, Q8RKD6, Q8RKD7, Q8RKD8, Q8RKD9, Q8RKE0
      Conserved Domains (1) summary
      PRK10172
      Location:1 → 432
      PRK10172; AppA family phytase/histidine-type acid phosphatase
    Nucleotide Protein
    Heading Accession and Version

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