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    wecB UDP-N-acetylglucosamine 2-epimerase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944789, updated on 3-Dec-2024

    Summary

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    Official Symbol
    wecB
    Official Full Name
    UDP-N-acetylglucosamine 2-epimerase
    Primary source
    ECOCYC:EG11451
    Locus tag
    b3786
    See related
    ASAP:ABE-0012372
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3778; mnaA; nfrC; rffE; yifF
    Summary
    Isolation of spontaneous N4 bacteriophage-resistant mutants of Escherichia coli K-12 strain SC1100, cloning of the affected genes, and subsequent complementation experiments revealed that nfrC is important in N4 adsorption . [More information is available at EcoCyc: EG11451].
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    Genomic context

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    Sequence:
    NC_000913.3 (3970133..3971263)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase Neighboring gene enterobacterial common antigen polysaccharide co-polymerase Neighboring gene UDP-N-acetyl-D-mannosamine dehydrogenase Neighboring gene dTDP-glucose 4,6-dehydratase 2 Neighboring gene glucose-1-phosphate thymidylyltransferase 2 Neighboring gene RffC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Active site mutants of the "non-hydrolyzing" UDP-N-acetylglucosamine 2-epimerase from Escherichia coli. Samuel J, et al. Biochim Biophys Acta, 2004 Jul 1. PMID 15210128
    2. The structure of UDP-N-acetylglucosamine 2-epimerase reveals homology to phosphoglycosyl transferases. Campbell RE, et al. Biochemistry, 2000 Dec 12. PMID 11106477
    3. Characterization of the dTDP-rhamnose biosynthetic genes encoded in the rfb locus of Shigella flexneri. Macpherson DF, et al. Mol Microbiol, 1994 Jan. PMID 8170390
    4. Enzymatic synthesis of uridine diphosphate N-acetyl-D-mannosaminuronic acid. Kawamura T, et al. J Biol Chem, 1979 Sep 10. PMID 381306
    5. Toxicity-based selection of Escherichia coli mutants for functional recombinant protein production: application to an antibody fragment. Belin P, et al. Protein Eng Des Sel, 2004 May. PMID 15252207

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables UDP-N-acetylglucosamine 2-epimerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-N-acetylglucosamine 2-epimerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in enterobacterial common antigen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in enterobacterial common antigen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UDP-N-acetylglucosamine 2-epimerase
    YP_026253.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3970133..3971263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_026253.1 UDP-N-acetylglucosamine 2-epimerase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for YP_026253.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N8R0G5
      Conserved Domains (1) summary
      TIGR00236
      Location:1 → 373
      wecB; UDP-N-acetylglucosamine 2-epimerase
    Nucleotide Protein
    Heading Accession and Version

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