U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    mlrA DNA-binding transcriptional activator MlrA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949029, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    mlrA
    Official Full Name
    DNA-binding transcriptional activator MlrA
    Primary source
    ECOCYC:EG12008
    Locus tag
    b2127
    See related
    ASAP:ABE-0007030
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2119; yehV
    Summary
    RpoS regulon. [More information is available at EcoGene: EG12008]. MlrA is a regulator of curli production in an avian pathogenic Escherichia coli strain and in Salmonella enterica serovar Typhimurium . [More information is available at EcoCyc: EG12008].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (2214866..2215597)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1456 domain-containing protein YehS Neighboring gene DNA-binding transcriptional dual regulator BtsR Neighboring gene high-affinity pyruvate receptor Neighboring gene UPF0387 family protein YohO Neighboring gene glycine betaine ABC transporter membrane subunit YehW Neighboring gene glycine betaine ABC transporter ATP binding subunit YehX Neighboring gene glycine betaine ABC transporter membrane subunit YehY

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Escherichia coli O157:H7 Shiga toxin-encoding bacteriophages: integrations, excisions, truncations, and evolutionary implications. Shaikh N, et al. J Bacteriol, 2003 Jun. PMID 12775697, Free PMC Article
    2. Phage insertion in mlrA and variations in rpoS limit curli expression and biofilm formation in Escherichia coli serotype O157: H7. Uhlich GA, et al. Microbiology (Reading), 2013 Aug. PMID 23744902
    3. Regulatory role of MlrA in transcription activation of csgD, the master regulator of biofilm formation in Escherichia coli. Ogasawara H, et al. FEMS Microbiol Lett, 2010 Nov. PMID 20874755
    4. MlrA, a novel regulator of curli (AgF) and extracellular matrix synthesis by Escherichia coli and Salmonella enterica serovar Typhimurium. Brown PK, et al. Mol Microbiol, 2001 Jul. PMID 11489123
    5. Insertion site occupancy by stx2 bacteriophages depends on the locus availability of the host strain chromosome. Serra-Moreno R, et al. J Bacteriol, 2007 Sep. PMID 17644594, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    DNA-binding transcriptional activator MlrA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2214866..2215597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416631.1 DNA-binding transcriptional activator MlrA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416631.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2GE05, A0A5B9AHY1
      Conserved Domains (1) summary
      PRK15043
      Location:1 → 243
      PRK15043; HTH-type transcriptional regulator MlrA
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.