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    mutH DNA mismatch repair protein MutH [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947299, updated on 17-Dec-2024

    Summary

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    Official Symbol
    mutH
    Official Full Name
    DNA mismatch repair protein MutH
    Primary source
    ECOCYC:EG10624
    Locus tag
    b2831
    See related
    ASAP:ABE-0009287
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2827; mutR; prv
    Summary
    MutH is a dGATC endonuclease in the MutHLS complex, the methyl-directed mismatch repair pathway . [More information is available at EcoCyc: EG10624].
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    Genomic context

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    Sequence:
    NC_000913.3 (2969662..2970351)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene RNA pyrophosphohydrolase Neighboring gene YgdT Neighboring gene PF03741 family inner membrane protein YgdQ Neighboring gene DUF903 domain-containing lipoprotein YgdR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Detection of protein-DNA interaction with a DNA probe: distinction between single-strand and double-strand DNA-protein interaction. Ban C, et al. Nucleic Acids Res, 2004 Jul 25. PMID 15273279, Free PMC Article
    2. Mutational analysis of the MutH protein from Escherichia coli. Loh T, et al. J Biol Chem, 2001 Apr 13. PMID 11124943
    3. Nucleotide sequence of the Escherichia coli mutH gene. Grafstrom RH, et al. Nucleic Acids Res, 1987 Apr 10. PMID 3031619, Free PMC Article
    4. Coupling distant sites in DNA during DNA mismatch repair. Kolodner RD, et al. Proc Natl Acad Sci U S A, 2007 Aug 7. PMID 17664420, Free PMC Article
    5. Protein roadblocks and helix discontinuities are barriers to the initiation of mismatch repair. Pluciennik A, et al. Proc Natl Acad Sci U S A, 2007 Jul 31. PMID 17620611, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of MutS-, and MutL-dependent activation of MutH and their roles in methyl-directed mismatch repair in vitro
      Title: Involvement of the beta clamp in methyl-directed mismatch repair in vitro.
    2. MutL recruits the Vsr and MutH to sites of DNA damage.
      Title: The Escherichia coli mismatch repair protein MutL recruits the Vsr and MutH endonucleases in response to DNA damage.
    3. N-terminus verified by Edman degradation on mature peptide
      Title: Nucleotide sequence of the Escherichia coli mutH gene.
    4. protein-protein interaction analysis between MutL and MutH
      Title: Mapping protein-protein interactions between MutL and MutH by cross-linking.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables T/G mismatch-specific endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mismatch repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mismatch repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mismatch repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA recombination NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mismatch repair complex IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of mismatch repair complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA mismatch repair protein MutH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2969662..2970351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417308.1 DNA mismatch repair protein MutH [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417308.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S0FLT6
      Conserved Domains (1) summary
      PRK05070
      Location:9 → 226
      PRK05070; DNA mismatch repair protein; Provisional
    Nucleotide Protein
    Heading Accession and Version

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