ftsN cell division protein FtsN [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: ftsN
Official Full Name: cell division protein FtsN
Primary source: ECOCYC:EG11529
Locus tag: b3933
See related: ASAP:ABE-0012850
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK3925; msgA
Summary: The ftsN gene is essential. [More information is available at EcoGene: EG11529]. FtsN is an essential cell division protein present at 3000-6000 molecules per cell . [More information is available at EcoCyc: EG11529].
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Genomic context

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Sequence:: NC_000913.3 (4122380..4123339, complement)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors discovered that FtsBLQ inhibits the glycosyltransferase activity of PBP1b and that this inhibition was antagonized by the PBP1b activators FtsN and LpoB.
Title: Regulation of the Peptidoglycan Polymerase Activity of PBP1b by Antagonist Actions of the Core Divisome Proteins FtsBLQ and FtsN.
results suggest that these bypass conditions enhance the weak interaction of FtsN with FtsA and its periplasmic partners so that the divisome proteins are brought to the Z-ring when the normal hierarchical pathway is disrupted.
Title: Disruption of divisome assembly rescued by FtsN-FtsA interaction in Escherichia coli.
The data indicate the cellular requirement of both FtsN and DedD for septation as well as RodZ for cell elongation to maintain the small rod morphology at temperatures near 8 degrees C.
Title: A requirement for cell elongation protein RodZ and cell division proteins FtsN and DedD to maintain the small rod morphology of Escherichia coli at growth temperatures near 8°C.
FtsN allosterically activates peptidoglycan synthesis by two pathways, one in the cytoplasm and involving FtsA, and the other in the periplasm and involving FtsQLB.
Title: Last but not least: new insights into how FtsN triggers constriction during Escherichia coli cell division.
overexpression of FtsN bypassed ZipA and a conserved motif in the cytoplasmic domain of FtsN was required for both the bypass and interaction with FtsA
Title: The bypass of ZipA by overexpression of FtsN requires a previously unknown conserved FtsN motif essential for FtsA-FtsN interaction supporting a model in which FtsA monomers recruit late cell division proteins to the Z ring.
FtsN acts on either side of the membrane to induce a conformational switch in both FtsA and the FtsBLQ subcomplex to de-repress septal peptidoglycan synthesis and membrane invagination.
Title: Roles for both FtsA and the FtsBLQ subcomplex in FtsN-stimulated cell constriction in Escherichia coli.
These data support a model in which FtsA-FtsN interaction recruits FtsN to the divisome, where it can then stimulate the peptidoglycan remodelling activities required for SPOR-dependent localization.
Title: A role for FtsA in SPOR-independent localization of the essential Escherichia coli cell division protein FtsN.
Authors suggest a model wherein the overexpression of TolQ sequesters FtsN, depleting this essential protein from the divisome during Gram-negative cell division.
Title: Overexpression of the Escherichia coli TolQ protein leads to a null-FtsN-like division phenotype.
results suggest that the FtsQ interaction with FtsN, although not strictly essential for the division process, at least in some conditions, plays a role in the proper formation or stability of the division machinery
Title: Essential and non-essential interactions in interactome networks: the Escherichia coli division proteins FtsQ-FtsN interaction.
The stability and function of the divisome is not guaranteed until FtsN is recruited.
Title: Role of Escherichia coli FtsN protein in the assembly and stability of the cell division ring.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables peptidoglycan binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in FtsZ-dependent cytokinesis	IEA Inferred from Electronic Annotation more info
involved_in FtsZ-dependent cytokinesis	NAS Non-traceable Author Statement more info	PubMed
involved_in cell division	IDA Inferred from Direct Assay more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	NAS Non-traceable Author Statement more info	PubMed
involved_in cell septum assembly	IEA Inferred from Electronic Annotation more info
involved_in division septum assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within division septum assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in division septum assembly	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cell division site	IEA Inferred from Electronic Annotation more info
located_in cell division site	NAS Non-traceable Author Statement more info	PubMed
located_in cell septum	IDA Inferred from Direct Assay more info	PubMed
located_in division septum	IDA Inferred from Direct Assay more info	PubMed
part_of divisome complex	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: cell division protein FtsN

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

4122380..4123339 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_418368.1 cell division protein FtsN [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_418368.1

Status: PROVISIONAL

UniProtKB/TrEMBL

W8SY83

Conserved Domains (1) summary

PRK10927
Location:1 → 319

PRK10927; cell division protein FtsN