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    hemE uroporphyrinogen decarboxylase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948497, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hemE
    Official Full Name
    uroporphyrinogen decarboxylase
    Primary source
    ECOCYC:EG11543
    Locus tag
    b3997
    See related
    ASAP:ABE-0013066
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3989
    Summary
    Uroporphyrinogen decarboxylase (hemE) operates at a branch point between heme and siroheme in heme biosynthesis, converting uroporphyrinogen to coproporphyrinogen rather than precorrin-2. [More information is available at EcoCyc: EG11543].
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    Genomic context

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    Sequence:
    NC_000913.3 (4197716..4198780)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene regulator of sigma D Neighboring gene RNA decapping hydrolase Neighboring gene endonuclease V Neighboring gene DUF416 domain-containing protein YjaG

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Location of the hemE gene on the physical map of Escherichia coli. Ineichen G, et al. J Bacteriol, 1993 Dec. PMID 8244953, Free PMC Article
    2. Characterization of a hemA/hemE mutant of E. coli and regulation of hemE. Pido S, et al. Cell Mol Biol (Noisy-le-grand), 1994 Nov. PMID 7849561
    3. Uroporphyrin-accumulating mutant of Escherichia coli K-12. Săsărman A, et al. J Bacteriol, 1975 Dec. PMID 1104578, Free PMC Article
    4. Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes. Blattner FR, et al. Nucleic Acids Res, 1993 Nov 25. PMID 8265357, Free PMC Article
    5. Genome-wide screening of genes required for swarming motility in Escherichia coli K-12. Inoue T, et al. J Bacteriol, 2007 Feb. PMID 17122336, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uroporphyrinogen decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables uroporphyrinogen decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uroporphyrinogen decarboxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within heme B biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heme biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within heme biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in porphyrin-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within porphyrin-containing compound biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in porphyrin-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protoporphyrinogen IX biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protoporphyrinogen IX biosynthetic process from glutamate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protoporphyrinogen IX biosynthetic process from glutamate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within uroporphyrinogen III biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uroporphyrinogen decarboxylase
    NP_418425.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4197716..4198780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418425.1 uroporphyrinogen decarboxylase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418425.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6L7CEP9, A0A8S7EK18
      Conserved Domains (1) summary
      PRK00115
      Location:2 → 349
      hemE; uroporphyrinogen decarboxylase; Validated
    Nucleotide Protein
    Heading Accession and Version

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