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    PGAP2 Post-GPI attachment to proteins 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33258, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PGAP2provided by FlyBase
    Official Full Name
    Post-GPI attachment to proteins 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0031284
    Locus tag
    Dmel_CG3876
    See related
    AllianceGenome:FB:FBgn0031284
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3876; Dmel\CG3876
    Summary
    Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in organism. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 3. Orthologous to human PGAP2 (post-GPI attachment to proteins 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PGAP2 in Genome Data Viewer
    Location:
    21E2-21E2; 2-1.5 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (818079..819508, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (818079..819508, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene DEAD box protein 21E2 Neighboring gene SAGA factor-like TAF6 Neighboring gene Peroxin 12 Neighboring gene uncharacterized protein Neighboring gene Clipper Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article
    2. GPI biosynthesis is essential for rhodopsin sorting at the trans-Golgi network in Drosophila photoreceptors. Satoh T, et al. Development, 2013 Jan 15. PMID 23250212
    3. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article
    4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    5. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Post-GPI attachment to proteins 2
    Names
    CG3876-PA
    PGAP2-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      818079..819508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134704.5 → NP_608548.1  Post-GPI attachment to proteins 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608548.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VPT7
      UniProtKB/TrEMBL
      G4LU67
      Related
      FBpp0077703
      Conserved Domains (1) summary
      pfam10277
      Location:19 → 240
      Frag1; Frag1/DRAM/Sfk1 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPT7.2 Q9VPT7

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