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    CG7149 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34063, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG7149provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031948
    Locus tag
    Dmel_CG7149
    See related
    AllianceGenome:FB:FBgn0031948
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cpt; dCCS3; Dmel\CG7149
    Summary
    Predicted to enable ethanolaminephosphotransferase activity. Predicted to be involved in phosphatidylethanolamine biosynthetic process. Located in Golgi apparatus. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval salivary gland; fat body; and larval central nervous system. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 81. Orthologous to human SELENOI (selenoprotein I). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG7149 in Genome Data Viewer
    Location:
    28C3-28C4; 2-28 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7786160..7790557, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7786160..7790557, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Bromodomain containing 7/9 Neighboring gene Lysine ketoglutarate reductase/saccharopine dehydrogenase Neighboring gene long non-coding RNA:CR44825 Neighboring gene Homocysteine-induced endoplasmic reticulum protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ceramide phosphoethanolamine biosynthesis in Drosophila is mediated by a unique ethanolamine phosphotransferase in the Golgi lumen. Vacaru AM, et al. J Biol Chem, 2013 Apr 19. PMID 23449981, Free PMC Article
    2. Autophagy-dependent rhodopsin degradation prevents retinal degeneration in Drosophila. Midorikawa R, et al. J Neurosci, 2010 Aug 11. PMID 20702701, Free PMC Article
    3. Lipid-gene regulatory network reveals coregulations of triacylglycerol with phosphatidylinositol/lysophosphatidylinositol and with hexosyl-ceramide. Wang W, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2019 Feb. PMID 30521938
    4. Innate immune signaling in Drosophila shifts anabolic lipid metabolism from triglyceride storage to phospholipid synthesis to support immune function. Martínez BA, et al. PLoS Genet, 2020 Nov. PMID 33227003, Free PMC Article
    5. A Drosophila LexA Enhancer-Trap Resource for Developmental Biology and Neuroendocrine Research. Kockel L, et al. G3 (Bethesda), 2016 Oct 13. PMID 27527793, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ethanolaminephosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphotransferase activity, for other substituted phosphate groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylethanolamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7149-PA
    CG7149-PB
    CG7149-PC
    NP_001285717.1
    NP_001285718.1
    NP_609149.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7786160..7790557 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298788.1 → NP_001285717.1  uncharacterized protein Dmel_CG7149, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285717.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J9T3
      Conserved Domains (1) summary
      cl00453
      Location:4 → 390
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    2. NM_001298789.1 → NP_001285718.1  uncharacterized protein Dmel_CG7149, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285718.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0S3, Q9VLX1
      Conserved Domains (1) summary
      cl00453
      Location:4 → 389
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    3. NM_135305.4 → NP_609149.3  uncharacterized protein Dmel_CG7149, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609149.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0S3, Q9VLX1
      Related
      FBpp0079119
      Conserved Domains (1) summary
      cl00453
      Location:4 → 389
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T0S3 Q8T0S3
    X2J9T3 X2J9T3

    Gene LinkOut

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