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    Adhr Adh-related [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3772432, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adhrprovided by FlyBase
    Official Full Name
    Adh-relatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000056
    Locus tag
    Dmel_CG3484
    See related
    AllianceGenome:FB:FBgn0000056
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    3'ORF; Adh-dup; ADHR; Adh[r]; ADH[r]; BG:DS01486.9; CG32954; CG3484; Dmel\CG3484
    Summary
    Predicted to be active in cytoplasm. Is expressed in several structures, including embryonic/larval garland cell; embryonic/larval midgut; ganglia; primordial germ cell; and visceral mesoderm derivative. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Adhr in Genome Data Viewer
    Location:
    35B3-35B3; 2-50 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14615552..14618902)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14615552..14618902)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene transfer RNA:Proline-AGG 1-4 Neighboring gene long non-coding RNA:CR43411 Neighboring gene outspread Neighboring gene Alcohol dehydrogenase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deletions at intervening sequence splice sites in the alcohol dehydrogenase gene of Drosophila. Benyajati C, et al. Nucleic Acids Res, 1982 Nov 25. PMID 6296769, Free PMC Article
    2. The Drosophila alcohol dehydrogenase gene may have evolved independently of the functionally homologous medfly, olive fly, and flesh fly genes. Brogna S, et al. Mol Biol Evol, 2001 Mar. PMID 11230533
    3. Structural analysis of an electrophoretically cryptic alcohol dehydrogenase variant from an Australian population of Drosophila melanogaster. Chambers GK, et al. Proc Natl Acad Sci U S A, 1981 May. PMID 6789328, Free PMC Article
    4. In vitro suppression of a nonsense mutant of Drosophila melanogaster. Kubli E, et al. Nucleic Acids Res, 1982 Nov 25. PMID 6818527, Free PMC Article
    5. Alcohol dehydrogenase gene of Drosophila melanogaster: relationship of intervening sequences to functional domains in the protein. Benyajati C, et al. Proc Natl Acad Sci U S A, 1981 May. PMID 6789320, Free PMC Article

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The translation mechanism of the dicistronic Adh-Adhr mRNA of Drosophila melanogaster, was investigated.
      Title: The intergenic spacer of the Drosophila Adh-Adhr dicistronic mRNA stimulates internal translation initiation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables NAD binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    NOT enables alcohol dehydrogenase (NAD+) activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    NOT enables oxidoreductase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Adh-related
    Names
    Adh related
    Adhr-PA
    Adhr-PB
    Adhr-PC
    CG3484-PA
    CG3484-PB
    CG3484-PC
    alcohol dehydrogenase related
    alcohol dehydrogenase-related

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      14615552..14618902
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058147.4 → NP_477495.1  Adh-related, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477495.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0Q4, P91615, Q24230, Q6LAE8, Q9NKB9, Q9VJS2
      UniProtKB/TrEMBL
      X2JAH0
      Conserved Domains (2) summary
      cd05323
      Location:7 → 248
      ADH_SDR_c_like; insect type alcohol dehydrogenase (ADH)-like, classical (c) SDRs
      pfam00106
      Location:7 → 195
      adh_short; short chain dehydrogenase

    2. NM_001032101.2 → NP_001027272.1  Adh-related, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027272.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0Q4, P91615, Q24230, Q6LAE8, Q9NKB9, Q9VJS2
      UniProtKB/TrEMBL
      X2JAH0
      Conserved Domains (2) summary
      cd05323
      Location:7 → 248
      ADH_SDR_c_like; insect type alcohol dehydrogenase (ADH)-like, classical (c) SDRs
      pfam00106
      Location:7 → 195
      adh_short; short chain dehydrogenase

    3. NM_001299009.1 → NP_001285938.1  Adh-related, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285938.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0Q4, P91615, Q24230, Q6LAE8, Q9NKB9, Q9VJS2
      UniProtKB/TrEMBL
      X2JAH0
      Conserved Domains (2) summary
      cd05323
      Location:7 → 248
      ADH_SDR_c_like; insect type alcohol dehydrogenase (ADH)-like, classical (c) SDRs
      pfam00106
      Location:7 → 195
      adh_short; short chain dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P91615.1 P91615
    X2JAH0 X2JAH0

    Gene LinkOut

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