Taf6 TBP-associated factor 6 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Taf6provided by FlyBase
Official Full Name: TBP-associated factor 6provided by FlyBase
Primary source: FLYBASE:FBgn0010417
Locus tag: Dmel_CG32211
See related: AllianceGenome:FB:FBgn0010417
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG32211; CG9348; d60; dme-TAFII60; Dmel\CG32211; dmTAF6; dTAF6; dTAF62; dTAFII62; dTAF[[II]]262; dTAF[[II]]60; dTAF[[II]]62; l(3)76BDf; p62; SR3-4B; TAF; Taf-6; taf6; TAF6; taf60; Taf60; TAF60; TAF60/62; Taf62; TAFII60; TAFII60(62); TAFII62; TAF[[II]]; Taf[[II]]60; TAF[[II]]60; TAF[[II]]60/62; TAF[[II]]62; TFIID; TFIID 62
Summary: Contributes to RNA polymerase II general transcription initiation factor activity. Involved in transcription by RNA polymerase II. Located in nucleus. Part of transcription factor TFIID complex. Is expressed in organism and spermatozoon. Orthologous to human TAF6 (TATA-box binding protein associated factor 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (19599088..19601382)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (19592188..19594482)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

HDAC6 regulates lipid droplet turnover in response to nutrient deprivation via p62-mediated selective autophagy
Title: HDAC6 regulates lipid droplet turnover in response to nutrient deprivation via p62-mediated selective autophagy.
TAF6 in flies is restricted to TFIID (TATA binding protein)
Title: A novel histone fold domain-containing protein that replaces TAF6 in Drosophila SAGA is required for SAGA-dependent gene expression.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to RNA polymerase II general transcription initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase II general transcription initiation factor activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II general transcription initiation factor activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA polymerase II preinitiation complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation at RNA polymerase II promoter	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
part_of SAGA complex	IEA Inferred from Electronic Annotation more info
part_of SLIK (SAGA-like) complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIID complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIID complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIID complex	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIID complex	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription factor TFIID complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Names: CG32211-PA; CG32211-PB; TBP associated factor 60; TBP-Associated factor 6; TBP-associated factor; TBP-associated factor 60; TBP-associated factor 60kD; Taf6-PA; Taf6-PB; suppressor of Ras85D 3-4B

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The following sections contain reference sequences that belong to a specific genome build. Explain