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    TBC1D23 TBC1 domain family member 23 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33289, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TBC1D23provided by FlyBase
    Official Full Name
    TBC1 domain family member 23provided by FlyBase
    Primary source
    FLYBASE:FBgn0031304
    Locus tag
    Dmel_CG4552
    See related
    AllianceGenome:FB:FBgn0031304
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4552; Dmel\CG4552; tbc1
    Summary
    Predicted to enable GTPase activator activity. Involved in positive regulation of intracellular transport. Located in recycling endosome and trans-Golgi network. Is expressed in several structures, including embryonic/larval midgut primordium; foregut primordium; gland; gut section; and hindgut proper primordium. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 11. Orthologous to human TBC1D23 (TBC1 domain family member 23). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TBC1D23 in Genome Data Viewer
    Location:
    21F1-21F1; 2-2 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1129316..1132411)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1129316..1132411)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Pinocchio Neighboring gene iris Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45717 Neighboring gene Major Facilitator Superfamily Transporter 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pinocchio, a novel protein expressed in the antenna, contributes to olfactory behavior in Drosophila melanogaster. Rollmann SM, et al. J Neurobiol, 2005 May. PMID 15719418
    2. Positive selection of Iris, a retroviral envelope-derived host gene in Drosophila melanogaster. Malik HS, et al. PLoS Genet, 2005 Oct. PMID 16244705, Free PMC Article
    3. CrebA increases secretory capacity through direct transcriptional regulation of the secretory machinery, a subset of secretory cargo, and other key regulators. Johnson DM, et al. Traffic, 2020 Sep. PMID 32613751, Free PMC Article
    4. Role of tbc1 in Drosophila embryonic salivary glands. Johnson DM, et al. BMC Mol Cell Biol, 2019 Jun 26. PMID 31242864, Free PMC Article
    5. An in vivo genetic screen in Drosophila identifies the orthologue of human cancer/testis gene SPO11 among a network of targets to inhibit lethal(3)malignant brain tumour growth. Rossi F, et al. Open Biol, 2017 Aug. PMID 28855394, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of intracellular transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle tethering to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TBC1 domain family member 23
    Names
    CG4552-PA
    TBC1D23-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1129316..1132411
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134725.2 → NP_608569.1  TBC1 domain family member 23 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608569.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MRS6, Q9VPW9
      Related
      FBpp0077621
      Conserved Domains (2) summary
      smart00450
      Location:330 → 429
      RHOD; Rhodanese Homology Domain
      pfam00566
      Location:34 → 233
      RabGAP-TBC; Rab-GTPase-TBC domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MRS6 Q8MRS6
    Q9VPW9 Q9VPW9

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