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    flfl falafel [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41675, updated on 9-Dec-2024

    Summary

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    Official Symbol
    flflprovided by FlyBase
    Official Full Name
    falafelprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024555
    Locus tag
    Dmel_CG9351
    See related
    AllianceGenome:FB:FBgn0024555
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9351; Dmel\CG9351; Flfl; l(3)L4179; PP4R3; Ppp4R3
    Summary
    Predicted to enable protein phosphatase activator activity. Involved in several processes, including asymmetric neuroblast division; basal protein localization; and negative regulation of peptidoglycan recognition protein signaling pathway. Located in chromosome, centromeric region; cytoplasm; and nucleus. Part of protein phosphatase 4 complex. Is expressed in several structures, including adult head; anterior endoderm anlage; central brain primordium; ganglia; and mesoderm. Orthologous to several human genes including PPP4R3A (protein phosphatase 4 regulatory subunit 3A) and PPP4R3B (protein phosphatase 4 regulatory subunit 3B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See flfl in Genome Data Viewer
    Location:
    87F10-87F11; 3-54 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13683921..13693905)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9509643..9519627)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene TWIK-related acid-sensitive K[+] channel 6 Neighboring gene uncharacterized protein Neighboring gene Lkb1 kinase Neighboring gene oocyte maintenance defects Neighboring gene uncharacterized protein Neighboring gene flyers-cup Neighboring gene neither inactivation nor afterpotential B Neighboring gene Adenosine deaminase-related growth factor D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of flfl Triggers JNK-Dependent Cell Death in Drosophila. Huang J, et al. Biomed Res Int, 2015. PMID 26583122, Free PMC Article
    2. Phosphorylation and dephosphorylation events allow for rapid segregation of fate determinants during Drosophila neuroblast asymmetric divisions. Sousa-Nunes R, et al. Commun Integr Biol, 2010 Jan. PMID 20539782, Free PMC Article
    3. Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases. Martin-Granados C, et al. Int J Biochem Cell Biol, 2008. PMID 18487071
    4. Slam protein dictates subcellular localization and translation of its own mRNA. Yan S, et al. PLoS Biol, 2017 Dec. PMID 29206227, Free PMC Article
    5. A fraction of barrier-to-autointegration factor (BAF) associates with centromeres and controls mitosis progression. Torras-Llort M, et al. Commun Biol, 2020 Aug 19. PMID 32814801, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kin17 regulates proper cortical localization of Miranda in Drosophila neuroblasts by regulating Flfl expression.
      Title: Kin17 regulates proper cortical localization of Miranda in Drosophila neuroblasts by regulating Flfl expression.
    2. These data report for the first time an essential physiological function of flfl in maintaining tissue homeostasis and organ development
      Title: Loss of flfl Triggers JNK-Dependent Cell Death in Drosophila.
    3. The binding of Flfl to CENP-C is required to bring PP4 activity to centromeres to maintain CENP-C and attached core kinetochore proteins at chromosomes during mitosis.
      Title: Centromeric binding and activity of Protein Phosphatase 4.
    4. identified the evolutionarily conserved Protein Phosphatase 4 (PP4) regulatory subunit PP4R3/Falafel (Flfl) as a key mediator specific for the localization of Miranda (Mira) and associated cell fate determinants during both interphase and mitosis
      Title: Protein phosphatase 4 mediates localization of the Miranda complex during Drosophila neuroblast asymmetric divisions.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in asymmetric neuroblast division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in basal protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome, centromeric region IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein phosphatase 4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase 4 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    falafel
    Names
    CG9351-PB
    CG9351-PD
    CG9351-PE
    flfl-PB
    flfl-PD
    flfl-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13683921..13693905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142047.4 → NP_650304.2  falafel, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650304.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VFS5
      Conserved Domains (2) summary
      pfam04802
      Location:169 → 361
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:8 → 66
      PH-like; Pleckstrin homology-like domain

    2. NM_169549.2 → NP_731850.2  falafel, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731850.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSX6, Q9VFS5
      UniProtKB/TrEMBL
      A0A0C4DHE6
      Conserved Domains (2) summary
      pfam04802
      Location:169 → 361
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:8 → 66
      PH-like; Pleckstrin homology-like domain

    3. NM_169548.3 → NP_731849.2  falafel, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731849.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSX6, Q9VFS5
      UniProtKB/TrEMBL
      A0A0C4DHE6
      Conserved Domains (2) summary
      pfam04802
      Location:169 → 361
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:8 → 66
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0C4DHE6 A0A0C4DHE6
    Q8MSW1 Q8MSW1
    Q9VFS5.4 Q9VFS5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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