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    Slc45-1 Solute carrier family 45 member 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39055, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc45-1provided by FlyBase
    Official Full Name
    Solute carrier family 45 member 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0035968
    Locus tag
    Dmel_CG4484
    See related
    AllianceGenome:FB:FBgn0035968
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4484; Dmel\CG4484; scrt
    Summary
    Enables sucrose transmembrane transporter activity. Involved in sucrose transport. Located in apical part of cell and cytoplasmic vesicle. Is expressed in adult head; embryonic/larval hindgut; follicle cell; and organism. Human ortholog(s) of this gene implicated in oculocutaneous albinism type IV and pigmentation disease. Orthologous to human SLC45A2 (solute carrier family 45 member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Slc45-1 in Genome Data Viewer
    Location:
    67A3-67A3; 3-28 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9203065..9208853, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9196165..9201953, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene nervous wreck Neighboring gene mir-4940 stem loop Neighboring gene Resistant to dieldrin Neighboring gene long non-coding RNA:CR45408 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of an animal sucrose transporter. Meyer H, et al. J Cell Sci, 2011 Jun 15. PMID 21586609
    2. Gene duplication in the major insecticide target site, Rdl, in Drosophila melanogaster. Remnant EJ, et al. Proc Natl Acad Sci U S A, 2013 Sep 3. PMID 23959864, Free PMC Article
    3. Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging. Rai M, et al. Cell Metab, 2021 Jun 1. PMID 33773104, Free PMC Article
    4. Glial solute carrier transporters in Drosophila and mice. Featherstone DE. Glia, 2011 Sep. PMID 21732427
    5. Genetics of alcohol consumption in Drosophila melanogaster. Fochler S, et al. Genes Brain Behav, 2017 Sep. PMID 28627812, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables sucrose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sucrose:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in sucrose transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 45 member 1
    Names
    CG4484-PA
    CG4484-PB
    CG4484-PC
    CG4484-PD
    Slc45 ortholog 1
    Slc45-1-PA
    Slc45-1-PB
    Slc45-1-PC
    Slc45-1-PD
    sucrose transporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9203065..9208853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140035.2 → NP_648292.1  solute carrier family 45 member 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648292.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSV1
      Related
      FBpp0076231
      Conserved Domains (2) summary
      cd06174
      Location:444 → 597
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR01301
      Location:49 → 568
      GPH_sucrose; GPH family sucrose/H+ symporter

    2. NM_001274689.1 → NP_001261618.1  solute carrier family 45 member 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261618.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSV1
      Conserved Domains (2) summary
      cd06174
      Location:444 → 597
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR01301
      Location:49 → 568
      GPH_sucrose; GPH family sucrose/H+ symporter

    3. NM_001274690.1 → NP_001261619.1  solute carrier family 45 member 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261619.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSV1
      Conserved Domains (2) summary
      cd06174
      Location:444 → 597
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR01301
      Location:49 → 568
      GPH_sucrose; GPH family sucrose/H+ symporter

    4. NM_001274691.1 → NP_001261620.1  solute carrier family 45 member 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261620.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSV1
      Conserved Domains (2) summary
      cd06174
      Location:444 → 597
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR01301
      Location:49 → 568
      GPH_sucrose; GPH family sucrose/H+ symporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VSV1 Q9VSV1

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