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    unc79 uncoordinated 79 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42310, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc79provided by FlyBase
    Official Full Name
    uncoordinated 79provided by FlyBase
    Primary source
    FLYBASE:FBgn0038693
    Locus tag
    Dmel_CG5237
    See related
    AllianceGenome:FB:FBgn0038693
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0153538.74; anon-WO0172774.15; CG5237; Dmel\CG5237; dunc79; Dunc79; DUNC79; UNC79
    Summary
    Involved in locomotor rhythm and response to anesthetic. Part of cation channel complex. Is expressed in adult head. Used to study syndromic intellectual disability. Orthologous to human UNC79 (unc-79 homolog, NALCN channel complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See unc79 in Genome Data Viewer
    Location:
    91F12-91F12; 3-66 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19230764..19246130, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15056486..15071852, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene RNA polymerase II subunit M Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new neurodevelopmental disorder linked to heterozygous variants in UNC79. Bayat A, et al. Genet Med, 2023 Sep. PMID 37183800
    2. The Narrow Abdomen Ion Channel Complex Is Highly Stable and Persists from Development into Adult Stages to Promote Behavioral Rhythmicity. Moose DL, et al. Front Cell Neurosci, 2017. PMID 28634443, Free PMC Article
    3. A screen for sleep and starvation resistance identifies a wake-promoting role for the auxiliary channel unc79. Murakami K, et al. G3 (Bethesda), 2021 Aug 7. PMID 34849820, Free PMC Article
    4. UNC79 and UNC80, putative auxiliary subunits of the NARROW ABDOMEN ion channel, are indispensable for robust circadian locomotor rhythms in Drosophila. Lear BC, et al. PLoS One, 2013. PMID 24223770, Free PMC Article
    5. New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN. Monteil A, et al. Physiol Rev, 2024 Jan 1. PMID 37615954

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NA, UNC79, and UNC80 function together in circadian clock neurons to promote rhythmic behavior.
      Title: UNC79 and UNC80, putative auxiliary subunits of the NARROW ABDOMEN ion channel, are indispensable for robust circadian locomotor rhythms in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to anesthetic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cation channel complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncoordinated 79
    Names
    CG5237-PB
    CG5237-PC
    CG5237-PD
    CG5237-PE
    CG5237-PF
    unc79-PB
    unc79-PC
    unc79-PD
    unc79-PE
    unc79-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19230764..19246130 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300474.1 → NP_001287403.1  uncoordinated 79, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287403.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LID2, Q06AJ1
      Conserved Domains (1) summary
      pfam14776
      Location:78 → 600
      UNC-79; Cation-channel complex subunit UNC-79

    2. NM_001300475.1 → NP_001287404.1  uncoordinated 79, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287404.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHB4, Q06AJ1
      Conserved Domains (1) summary
      pfam14776
      Location:78 → 600
      UNC-79; Cation-channel complex subunit UNC-79

    3. NM_001170181.1 → NP_001163652.1  uncoordinated 79, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163652.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIP9, Q06AJ1
      Conserved Domains (1) summary
      pfam14776
      Location:78 → 600
      UNC-79; Cation-channel complex subunit UNC-79

    4. NM_142538.2 → NP_650795.2  uncoordinated 79, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650795.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q06AJ1, Q9VDY5
      Conserved Domains (1) summary
      pfam14776
      Location:78 → 600
      UNC-79; Cation-channel complex subunit UNC-79

    5. NM_001170182.2 → NP_001163653.1  uncoordinated 79, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163653.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIQ0, Q6NKM8
      Conserved Domains (1) summary
      pfam14776
      Location:78 → 600
      UNC-79; Cation-channel complex subunit UNC-79
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LHB4 A0A0B4LHB4
    A0A0B4LID2 A0A0B4LID2
    E1JIP9 E1JIP9
    E1JIQ0 E1JIQ0
    Q06AJ1 Q06AJ1
    Q961X5 Q961X5
    Q9VDY5 Q9VDY5

    Gene LinkOut

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