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    Nepl13 Neprilysin-like 13 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42699, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nepl13provided by FlyBase
    Official Full Name
    Neprilysin-like 13provided by FlyBase
    Primary source
    FLYBASE:FBgn0039022
    Locus tag
    Dmel_CG4725
    See related
    AllianceGenome:FB:FBgn0039022
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4725; Dmel\CG4725
    Summary
    Predicted to be involved in proteolysis. Located in extracellular region. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nepl13 in Genome Data Viewer
    Location:
    94C4-94C4; 3-76 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22758810..22761076, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18584532..18586798, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Heterochromatin Protein 1c Neighboring gene uncharacterized protein Neighboring gene Ubiquitin-specific protease 12/46 Neighboring gene rumi Neighboring gene uncharacterized protein Neighboring gene Neprilysin-like 14 Neighboring gene Neprilysin-like 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila. Sitnik JL, et al. Genetics, 2014 Mar. PMID 24395329, Free PMC Article
    2. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article
    3. Proteomic analysis of the Drosophila larval hemolymph clot. Karlsson C, et al. J Biol Chem, 2004 Dec 10. PMID 15466469
    4. Reproductive status alters transcriptomic response to infection in female Drosophila melanogaster. Short SM, et al. G3 (Bethesda), 2013 May 20. PMID 23550122, Free PMC Article
    5. Bioinformatic analysis of the neprilysin (M13) family of peptidases reveals complex evolutionary and functional relationships. Bland ND, et al. BMC Evol Biol, 2008 Jan 23. PMID 18215274, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Neprilysin-like 13
    Names
    CG4725-PA
    Nepl13-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22758810..22761076 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142839.4 → NP_651096.1  Neprilysin-like 13 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651096.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4XVL8, Q9VCU3
      Related
      FBpp0083712
      Conserved Domains (2) summary
      cd08662
      Location:68 → 738
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:63 → 732
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VCU3 Q9VCU3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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