Ald2 Aldolase 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ald2provided by FlyBase
Official Full Name: Aldolase 2provided by FlyBase
Primary source: FLYBASE:FBgn0039425
Locus tag: Dmel_CG5432
See related: AllianceGenome:FB:FBgn0039425
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Ald; CG5432; Dmel\CG5432
Summary: Predicted to enable fructose-1-phosphate aldolase activity and fructose-bisphosphate aldolase activity. Predicted to be involved in fructose 1,6-bisphosphate metabolic process; glyceraldehyde-3-phosphate metabolic process; and hexose metabolic process. Predicted to be active in cytosol. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in hereditary fructose intolerance syndrome and type 2 diabetes mellitus. Orthologous to human ALDOB (aldolase, fructose-bisphosphate B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (26414088..26416192)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (22239810..22241914)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables fructose-1-phosphate aldolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables fructose-bisphosphate aldolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fructose-bisphosphate aldolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in canonical glycolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in fructose 1,6-bisphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose 1,6-bisphosphate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in fructose catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in glyceraldehyde-3-phosphate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

NP_001247314.1

NP_651476.1

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The following sections contain reference sequences that belong to a specific genome build. Explain