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    pHCl-1 pH-sensitive chloride channel 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39730, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pHCl-1provided by FlyBase
    Official Full Name
    pH-sensitive chloride channel 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0264908
    Locus tag
    Dmel_CG44099
    See related
    AllianceGenome:FB:FBgn0264908
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH21757; BP1024; CG12486; CG13444; CG33989; CG44099; CG6112; CT19189; Dmel\CG44099; pHCl; pHCL-A
    Old locus tag
    Dmel_CG12486; Dmel_CG33989
    Summary
    Enables pH-gated chloride channel activity. Involved in chloride transmembrane transport. Located in membrane. Is expressed in several structures, including adult central brain; adult gut; adult optic lobe; adult ventral nerve cord; and organism subdivision. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pHCl-1 in Genome Data Viewer
    Location:
    72A2-72A4; 3-43 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15848578..15899029, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15841678..15892129, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mir-263b stem loop Neighboring gene meru Neighboring gene long non-coding RNA:CR44051 Neighboring gene long non-coding RNA:CR44050 Neighboring gene sugar-free frosting Neighboring gene Protein kinase, cAMP-dependent, catalytic subunit 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The orphan pentameric ligand-gated ion channel pHCl-2 is gated by pH and regulates fluid secretion in Drosophila Malpighian tubules. Feingold D, et al. J Exp Biol, 2016 Sep 1. PMID 27358471
    2. Motivation, Perception, and Chance Converge to Make a Binary Decision. Zhang SX, et al. Neuron, 2018 Jul 25. PMID 29983326, Free PMC Article
    3. A novel chloride channel in Drosophila melanogaster is inhibited by protons. Schnizler K, et al. J Biol Chem, 2005 Apr 22. PMID 15713676
    4. Putative histamine-gated chloride channel subunits of the insect visual system and thoracic ganglion. Witte I, et al. J Neurochem, 2002 Nov. PMID 12390512
    5. Evolution, Expression, and Function of Nonneuronal Ligand-Gated Chloride Channels in Drosophila melanogaster. Remnant EJ, et al. G3 (Bethesda), 2016 Jul 7. PMID 27172217, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data implicate pHCl-2 as an important source of chloride conductance required for proper urine production.
      Title: The orphan pentameric ligand-gated ion channel pHCl-2 is gated by pH and regulates fluid secretion in Drosophila Malpighian tubules.
    2. new branch of ligand-gated ion channels in invertebrates
      Title: A novel chloride channel in Drosophila melanogaster is inhibited by protons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pH-gated chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pH-sensitive chloride channel 1
    Names
    CG44099-PC
    CG44099-PD
    CG44099-PE
    CG44099-PF
    CG44099-PG
    CG44099-PH
    CG44099-PI
    CG44099-PJ
    CG44099-PK
    CG44099-PL
    CG44099-PM
    CG44099-PN
    CG44099-PO
    CG44099-PP
    CG44099-PS
    CG44099-PT
    CG44099-PU
    glutamate-gated chloride channel-like
    pH-sensitive chloride channel
    pHCl
    pHCl-1-PC
    pHCl-1-PD
    pHCl-1-PE
    pHCl-1-PF
    pHCl-1-PG
    pHCl-1-PH
    pHCl-1-PI
    pHCl-1-PJ
    pHCl-1-PK
    pHCl-1-PL
    pHCl-1-PM
    pHCl-1-PN
    pHCl-1-PO
    pHCl-1-PP
    pHCl-1-PS
    pHCl-1-PT
    pHCl-1-PU

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15848578..15899029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274967.1 → NP_001261896.1  pH-sensitive chloride channel 1, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261896.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFR7
      Conserved Domains (3) summary
      TIGR00860
      Location:332 → 743
      LIC; Cation transporter family protein
      pfam02931
      Location:331 → 534
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:546 → 740
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    2. NM_001274969.1 → NP_001261898.1  pH-sensitive chloride channel 1, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261898.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PI70
      Conserved Domains (2) summary
      pfam02931
      Location:338 → 566
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:578 → 682
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    3. NM_001370026.1 → NP_001356909.1  pH-sensitive chloride channel 1, isoform U [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JGQ0
      Conserved Domains (1) summary
      TIGR00860
      Location:332 → 751
      LIC; Cation transporter family protein

    4. NM_001274966.1 → NP_001261895.1  pH-sensitive chloride channel 1, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261895.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFD4
      Conserved Domains (3) summary
      TIGR00860
      Location:332 → 742
      LIC; Cation transporter family protein
      pfam02931
      Location:331 → 534
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:546 → 739
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    5. NM_001370024.1 → NP_001356981.1  pH-sensitive chloride channel 1, isoform S [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4D6K8E5
      Conserved Domains (1) summary
      TIGR00860
      Location:332 → 768
      LIC; Cation transporter family protein

    6. NM_001274965.1 → NP_001261894.1  pH-sensitive chloride channel 1, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261894.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCN0
      Conserved Domains (3) summary
      TIGR00860
      Location:332 → 768
      LIC; Cation transporter family protein
      pfam02931
      Location:331 → 559
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:571 → 765
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    7. NM_001259853.1 → NP_001246782.1  pH-sensitive chloride channel 1, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246782.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFY2
      Conserved Domains (3) summary
      TIGR00860
      Location:339 → 750
      LIC; Cation transporter family protein
      pfam02931
      Location:338 → 541
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:553 → 747
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    8. NM_001259852.1 → NP_001246781.1  pH-sensitive chloride channel 1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246781.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NEB0
      Conserved Domains (3) summary
      TIGR00860
      Location:339 → 758
      LIC; Cation transporter family protein
      pfam02931
      Location:338 → 566
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:578 → 755
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    9. NM_001370025.1 → NP_001356910.1  pH-sensitive chloride channel 1, isoform T [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JCG3
      Conserved Domains (1) summary
      TIGR00860
      Location:339 → 766
      LIC; Cation transporter family protein

    10. NM_001038934.4 → NP_001034023.2  pH-sensitive chloride channel 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034023.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUV2
      Conserved Domains (3) summary
      TIGR00860
      Location:339 → 733
      LIC; Cation transporter family protein
      pfam02931
      Location:338 → 541
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:553 → 730
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    11. NM_001038936.4 → NP_001034025.2  pH-sensitive chloride channel 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034025.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2PDZ0
      Conserved Domains (3) summary
      TIGR00860
      Location:339 → 758
      LIC; Cation transporter family protein
      pfam02931
      Location:338 → 566
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:578 → 755
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    12. NM_001274970.1 → NP_001261899.1  pH-sensitive chloride channel 1, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261899.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCN5
      Conserved Domains (2) summary
      pfam02931
      Location:331 → 534
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:546 → 717
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    13. NM_001274971.1 → NP_001261900.1  pH-sensitive chloride channel 1, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261900.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFD7
      Conserved Domains (3) summary
      TIGR00860
      Location:332 → 750
      LIC; Cation transporter family protein
      pfam02931
      Location:331 → 559
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:571 → 747
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    14. NM_001274968.1 → NP_001261897.1  pH-sensitive chloride channel 1, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261897.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFL8
      Conserved Domains (2) summary
      pfam02931
      Location:331 → 559
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:571 → 742
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    15. NM_001169979.1 → NP_001163450.1  pH-sensitive chloride channel 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163450.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JI08
      Conserved Domains (2) summary
      pfam02931
      Location:338 → 566
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:578 → 666
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    16. NM_001038935.3 → NP_001034024.2  pH-sensitive chloride channel 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034024.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2PDY9
      Conserved Domains (3) summary
      TIGR00860
      Location:339 → 775
      LIC; Cation transporter family protein
      pfam02931
      Location:338 → 566
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:578 → 772
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    17. NM_001038937.2 → NP_001034026.1  pH-sensitive chloride channel 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034026.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL69, Q9VUV3
      Conserved Domains (1) summary
      pfam02931
      Location:338 → 524
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A4D6K8E5 A0A4D6K8E5
    E1JI08 E1JI08
    M9NEB0 M9NEB0
    M9NFY2 M9NFY2
    M9PCN0 M9PCN0
    M9PCN5 M9PCN5
    M9PFD4 M9PFD4
    M9PFD7 M9PFD7
    M9PFL8 M9PFL8
    M9PFR7 M9PFR7
    M9PI70 M9PI70
    Q2PDY9 Q2PDY9
    Q2PDZ0 Q2PDZ0
    Q5D6V9 Q5D6V9
    Q5D6W0 Q5D6W0
    Q5D6W1 Q5D6W1
    Q95T52 Q95T52
    Q9VUV2 Q9VUV2
    Q9VUV3 Q9VUV3
    X2JCG3 X2JCG3
    X2JGQ0 X2JGQ0

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