otu ovarian tumor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: otuprovided by FlyBase
Official Full Name: ovarian tumorprovided by FlyBase
Primary source: FLYBASE:FBgn0003023
Locus tag: Dmel_CG12743
See related: AllianceGenome:FB:FBgn0003023
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12743; Dmel\CG12743; DROOTUA; fs(1)231; fs(1)23l; fs(1)jA265; fs(1)M101; fs(1)otu; K; Otu; OTU
Summary: Enables deubiquitinase activity; mRNA binding activity; and serine-type peptidase activity. Involved in several processes, including germarium-derived egg chamber formation; negative regulation of peptidoglycan recognition protein signaling pathway; and positive regulation of DNA endoreduplication. Located in cytoplasmic ribonucleoprotein granule and cytosol. Is expressed in several structures, including egg chamber; germarium; germarium region 1; germline cell; and gonad. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 36. Orthologous to several human genes including OTUD4 (OTU deubiquitinase 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 7F1-7F1; 1-23 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (8485008..8489535, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (8379041..8383568, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Otu and Rif1 Double Mutant Enables Analysis of Satellite DNA in Polytene Chromosomes of Ovarian Germ Cells in Drosophila melanogaster.
Title: Otu and Rif1 Double Mutant Enables Analysis of Satellite DNA in Polytene Chromosomes of Ovarian Germ Cells in Drosophila melanogaster.
oalescence-mediated enzymatic activity of Otu is positively regulated by its bound RNAs and co-partner Bam. Further genetic analysis reveals that the Otu/Bam deubiquitinase complex and dTraf6 constitute a feedback loop to maintain intestinal immune homeostasis during aging, thereby controlling longevity.
Title: LC Domain-Mediated Coalescence Is Essential for Otu Enzymatic Activity to Extend Drosophila Lifespan.
There is an evolutionary loss of activity in de-ubiquitylating enzymes of the OTU family, OTUD4, otu, and CG3251.
Title: Evolutionary Loss of Activity in De-Ubiquitylating Enzymes of the OTU Family.
Mutations in ovarian tumor (otu) interfere with both Sxl germline functions.
Title: Effects of Wolbachia infection and ovarian tumor mutations on Sex-lethal germline functioning in Drosophila.
an examination of chromosomes in otu mutants of Drosophila melanogaster in ovarian nurse cells
Title: Polytene chromosomes from ovarian nurse cells of Drosophila melanogaster otu mutants.
Data show that Squid (Sqd) interacts with Hrb27C, and that Ovarian tumor (Otu) cooperates with Hrb27C and Sqd in the oocyte to mediate proper gurken (grk) localization.
Title: Hrb27C, Sqd and Otu cooperatively regulate gurken RNA localization and mediate nurse cell chromosome dispersion in Drosophila oogenesis.
ovarian tumour has a specific role in the developmentally regulated accumulation of sex-lehtal protein within the cytoplasm and nucleus.
Title: The involvement of ovarian tumour in the intracellular localization of Sex-lethal protein.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables K63-linked deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables deubiquitinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables serine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type peptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female germ-line sex determination	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of germarium-derived cystoblast division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived female germ-line cyst formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived oocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of ovarian fusome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA endoreduplication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasmic ribonucleoprotein granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ovarian tumor

Names: CG12743-PA; CG12743-PB; CG12743-PC; CG12743-PD; CG12743-PE; otu-PA; otu-PB; otu-PC; otu-PD; otu-PE; ovarian tumour

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

8485008..8489535 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272403.1 → NP_001259332.1 ovarian tumor, isoform D [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

H5V8A9

Conserved Domains (2) summary

cl19932
Location:37 → 115

OTU; OTU-like cysteine protease

cl22931
Location:404 → 522

TAF12; TATA Binding Protein (TBP) Associated Factor 12 (TAF12) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
NM_167158.3 → NP_727271.1 ovarian tumor, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

H5V8A9

Related

FBpp0071180

Conserved Domains (2) summary

cl19932
Location:37 → 115

OTU; OTU-like cysteine protease

cl22931
Location:404 → 522

TAF12; TATA Binding Protein (TBP) Associated Factor 12 (TAF12) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
NM_078534.4 → NP_511089.2 ovarian tumor, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V451, P10383, Q8SYF4, Q9GYD8, Q9TWA9, Q9W3E4

Related

FBpp0071181

Conserved Domains (3) summary

smart00333
Location:335 → 392

TUDOR; Tudor domain

cl19932
Location:37 → 115

OTU; OTU-like cysteine protease

cl22931
Location:446 → 564

TAF12; TATA Binding Protein (TBP) Associated Factor 12 (TAF12) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
NM_206656.2 → NP_996379.1 ovarian tumor, isoform C [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V451, P10383, Q8SYF4, Q9GYD8, Q9TWA9, Q9W3E4

Conserved Domains (3) summary

smart00333
Location:335 → 392

TUDOR; Tudor domain

cl19932
Location:37 → 115

OTU; OTU-like cysteine protease

cl22931
Location:446 → 564

TAF12; TATA Binding Protein (TBP) Associated Factor 12 (TAF12) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
NM_001272404.1 → NP_001259333.1 ovarian tumor, isoform E [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

H5V8A9

Conserved Domains (2) summary

cl19932
Location:37 → 115

OTU; OTU-like cysteine protease

cl22931
Location:404 → 522

TAF12; TATA Binding Protein (TBP) Associated Factor 12 (TAF12) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex