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    Pfdn4 Prefoldin 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38615, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pfdn4provided by FlyBase
    Official Full Name
    Prefoldin 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0035603
    Locus tag
    Dmel_CG10635
    See related
    AllianceGenome:FB:FBgn0035603
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:SD11994; CG10635; Dmel\CG10635; pfdn4
    Summary
    Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be part of prefoldin complex. Predicted to be active in cytoplasm. Orthologous to human PFDN4 (prefoldin subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pfdn4 in Genome Data Viewer
    Location:
    64C13-64C14; 3-13 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5367341..5368008, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5360441..5361108, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cytochrome c1 Neighboring gene Ubiquitin-conjugating enzyme variant 1A Neighboring gene membrin Neighboring gene long non-coding RNA:CR44515 Neighboring gene long non-coding RNA:CR44516

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Prefoldin and Pins synergistically regulate asymmetric division and suppress dedifferentiation. Zhang Y, et al. Sci Rep, 2016 Mar 30. PMID 27025979, Free PMC Article
    2. Misato Controls Mitotic Microtubule Generation by Stabilizing the TCP-1 Tubulin Chaperone Complex [corrected]. Palumbo V, et al. Curr Biol, 2015 Jun 29. PMID 26096973, Free PMC Article
    3. A genetic screen identifies new regulators of steroid-triggered programmed cell death in Drosophila. Wang L, et al. Genetics, 2008 Sep. PMID 18757938, Free PMC Article
    4. The genomic response to courtship song stimulation in female Drosophila melanogaster. Immonen E, et al. Proc Biol Sci, 2012 Apr 7. PMID 21976688, Free PMC Article
    5. Characterization of gene expression regulated by human OTK18 using Drosophila melanogaster as a model system for innate immunity. Spresser CR, et al. J Genet, 2008 Aug. PMID 18776638

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of prefoldin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of prefoldin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    prefoldin 4
    Names
    CG10635-PA
    Pfdn4-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5367341..5368008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139704.2 → NP_647961.1  prefoldin 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647961.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VRL3
      UniProtKB/TrEMBL
      A0A1B2AKD0, Q8MRY9
      Related
      FBpp0076858
      Conserved Domains (1) summary
      pfam01920
      Location:26 → 129
      Prefoldin_2; Prefoldin subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MRY9 Q8MRY9
    Q9VRL3.1 Q9VRL3

    Gene LinkOut

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