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    Scp2 Sarcoplasmic calcium-binding protein 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42015, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Scp2provided by FlyBase
    Official Full Name
    Sarcoplasmic calcium-binding protein 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0020907
    Locus tag
    Dmel_CG14904
    See related
    AllianceGenome:FB:FBgn0020907
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CE; cex; Cex; CG14904; CG17597; Dcabp-A.2; Dmel\CG14904; dSCP2; JHDK; SCP2; ScpX; SCPx
    Summary
    Enables GTPase activity. Is expressed in several structures, including Malpighian tubule primordium; adult head; brain; embryonic Malpighian tubule tip cell; and larval ventral nerve cord. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Scp2 in Genome Data Viewer
    Location:
    89B20-89D4; 3-59 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16574543..16583663, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12400265..12409385, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene neuropeptide F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Calcium-regulated GTPase activity in the calcium-binding protein calexcitin. Nelson TJ, et al. Comp Biochem Physiol B Biochem Mol Biol, 2003 Aug. PMID 12892754
    2. Identification of a gene family from Drosophila melanogaster encoding proteins with homology to invertebrate sarcoplasmic calcium-binding proteins (SCPS). Kelly LE, et al. Insect Biochem Mol Biol, 1997 Aug-Sep. PMID 9443378
    3. Juvenile hormone diol kinase. II. Sequencing, cloning, and molecular modeling of juvenile hormone-selective diol kinase from Manduca sexta. Maxwell RA, et al. J Biol Chem, 2002 Jun 14. PMID 11909870
    4. The products of the Drosophila stoned locus interact with synaptic vesicles via synaptotagmin. Phillips AM, et al. J Neurosci, 2000 Nov 15. PMID 11069931, Free PMC Article
    5. Sex- and segment-specific modulation of gene expression profiles in Drosophila. Barmina O, et al. Dev Biol, 2005 Dec 15. PMID 16269142

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sarcoplasmic calcium-binding protein 2
    Names
    CG14904-PA
    Ca2+-sensing low molecular weight GTPase
    Cex Ca2+-sensing low molecular weight
    Scp2-PA
    calexcitin
    drosophila Ca[2+]-binding protein A.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16574543..16583663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079657.4 → NP_524381.1  sarcoplasmic calcium-binding protein 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524381.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16158
      Related
      FBpp0082806
      Conserved Domains (3) summary
      COG5126
      Location:71 → 163
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam13499
      Location:14 → 86
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:10 → 87
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O16158 O16158

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