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    tst twister [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42813, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tstprovided by FlyBase
    Official Full Name
    twisterprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039117
    Locus tag
    Dmel_CG10210
    See related
    AllianceGenome:FB:FBgn0039117
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg10210; CG10210; Dmel\CG10210; dSki2; Ski2; SKI2; Ski2/tst
    Summary
    Predicted to enable RNA helicase activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleus. Predicted to be part of Ski complex. Is expressed in adult head; anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Human ortholog(s) of this gene implicated in trichohepatoenteric syndrome 2. Orthologous to human SKIC2 (SKI2 subunit of superkiller complex). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tst in Genome Data Viewer
    Location:
    95B1-95B1; 3-80 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23768399..23772859, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19594121..19598581, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene undicht Neighboring gene Lipid storage droplet-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Nucleoporin 98-96kD

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila gene twister, an orthologue of the yeast helicase SKI2, is differentially expressed during development. Seago JE, et al. Mech Dev, 2001 Aug. PMID 11472843
    2. Analysis of Dom34 and its function in no-go decay. Passos DO, et al. Mol Biol Cell, 2009 Jul. PMID 19420139, Free PMC Article
    3. Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila. Gatfield D, et al. Nature, 2004 Jun 3. PMID 15175755
    4. An enemy within: fly reconnaissance deploys an endonuclease to destroy nonsense-containing mRNA. Valencia-Sánchez MA, et al. Trends Cell Biol, 2004 Nov. PMID 15519847
    5. A conserved virus-induced cytoplasmic TRAMP-like complex recruits the exosome to target viral RNA for degradation. Molleston JM, et al. Genes Dev, 2016 Jul 15. PMID 27474443, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
    Component Evidence Code Pubs
    part_of Ski complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    twister
    Names
    CG10210-PA
    CG10210-PB
    tst-PA
    tst-PB
    NP_001262884.1
    NP_524465.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23768399..23772859 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079741.3 → NP_524465.1  twister, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524465.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RK2, Q9BI21, Q9VCH8
      Related
      FBpp0083853
      Conserved Domains (5) summary
      smart00490
      Location:578 → 658
      HELICc; helicase superfamily c-terminal domain
      COG4581
      Location:193 → 1194
      Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
      pfam00270
      Location:267 → 414
      DEAD; DEAD/DEAH box helicase
      pfam08148
      Location:1025 → 1188
      DSHCT; DSHCT (NUC185) domain
      pfam13234
      Location:715 → 996
      rRNA_proc-arch; rRNA-processing arch domain

    2. NM_001275955.1 → NP_001262884.1  twister, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262884.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RK2, Q9BI21, Q9VCH8
      Conserved Domains (5) summary
      smart00490
      Location:578 → 658
      HELICc; helicase superfamily c-terminal domain
      COG4581
      Location:193 → 1194
      Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
      pfam00270
      Location:267 → 414
      DEAD; DEAD/DEAH box helicase
      pfam08148
      Location:1025 → 1188
      DSHCT; DSHCT (NUC185) domain
      pfam13234
      Location:715 → 996
      rRNA_proc-arch; rRNA-processing arch domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BI21 Q9BI21
    Q9VCH8 Q9VCH8

    Gene LinkOut

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