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    Larp7 La related protein 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44900, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Larp7provided by FlyBase
    Official Full Name
    La related protein 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0260771
    Locus tag
    Dmel_CG42569
    See related
    AllianceGenome:FB:FBgn0260771
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12058; CG42569; dLARP7; Dmel\CG42569; dmLarp7
    Old locus tag
    Dmel_CG12058
    Summary
    Enables 7SK snRNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Part of 7SK snRNP. Is expressed in several structures, including egg chamber; embryonic/larval fat body; embryonic/larval gut; embryonic/larval salivary gland; and gastric caecum. Orthologous to human LARP7 (La ribonucleoprotein 7, transcriptional regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Larp7 in Genome Data Viewer
    Location:
    8D2-8D2; 1-27 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9243817..9245925)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9137850..9139958)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 8a Neighboring gene mir-4916 stem loop Neighboring gene multi sex combs Neighboring gene almondex Neighboring gene Downstream of raf1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An alternative D. melanogaster 7SK snRNP. Nguyen D, et al. BMC Mol Cell Biol, 2021 Aug 31. PMID 34461828, Free PMC Article
    2. The Drosophila 7SK snRNP and the essential role of dHEXIM in development. Nguyen D, et al. Nucleic Acids Res, 2012 Jul. PMID 22379134, Free PMC Article
    3. Regulation of larval hematopoiesis in Drosophila melanogaster: a role for the multi sex combs gene. Remillieux-Leschelle N, et al. Genetics, 2002 Nov. PMID 12454071, Free PMC Article
    4. A comprehensive Drosophila resource to identify key functional interactions between SARS-CoV-2 factors and host proteins. Guichard A, et al. Cell Rep, 2023 Aug 29. PMID 37480566, Free PMC Article
    5. Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library. Lowe N, et al. Development, 2014 Oct. PMID 25294943, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. One of the regulatory inputs in larval hematopoiesis that control normal rates of plasmatocyte and crystal lineage proliferation.
      Title: Regulation of larval hematopoiesis in Drosophila melanogaster: a role for the multi sex combs gene.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 7SK snRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of transcription elongation by RNA polymerase II IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of 7SK snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    La related protein 7
    Names
    CG42569-PA
    Larp7-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9243817..9245925
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080056.6 → NP_524795.2  La related protein 7 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524795.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KJ96, Q9W362
      Related
      FBpp0290490
      Conserved Domains (4) summary
      smart00715
      Location:57 → 135
      LA; Domain in the RNA-binding Lupus La protein; unknown function
      COG0724
      Location:116 → 208
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12290
      Location:148 → 209
      RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
      cd12542
      Location:471 → 548
      RRM2_LARP7; RNA recognition motif 2 in La-related protein 7 (LARP7) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W362 Q9W362

    Gene LinkOut

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