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    Mocs2B Molybdenum cofactor synthesis 2B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43017, updated on 4-Jan-2025

    Summary

    Official Symbol
    Mocs2Bprovided by FlyBase
    Official Full Name
    Molybdenum cofactor synthesis 2Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039280
    Locus tag
    Dmel_CG10238
    See related
    AllianceGenome:FB:FBgn0039280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10238; dMbip; Dmel\CG10238; dMoaE; Dromel_CG10238_FBtr0084782_mocs_mORF; Mbip; MBIP/dMoaE; Mocs2; MOCS2; Mocs2b
    Summary
    Predicted to contribute to molybdopterin synthase activity. Involved in chromatin remodeling and molybdopterin cofactor biosynthetic process. Located in polytene chromosome. Part of ATAC complex. Is expressed in organism. Used to study molybdenum cofactor deficiency type B. Human ortholog(s) of this gene implicated in molybdenum cofactor deficiency type B. Orthologous to human MOCS2 (molybdenum cofactor synthesis 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mocs2B in Genome Data Viewer
    Location:
    96C1-96C1; 3-87 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25125632..25127359, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20951354..20953081, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Tubulin tyrosine ligase-like 5 Neighboring gene uncharacterized protein Neighboring gene vig2 Neighboring gene Molybdenum cofactor synthesis 2A Neighboring gene Caliban Neighboring gene Band4.1 inhibitor LRP interactor

    Genomic regions, transcripts, and products

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molybdopterin synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to molybdopterin synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in Mo-molybdopterin cofactor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Mo-molybdopterin cofactor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in molybdopterin cofactor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of ATAC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ATAC complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of molybdopterin synthase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of molybdopterin synthase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    molybdenum cofactor synthesis 2B
    Names
    CG10238-PA
    MAPK upstream kinase-binding inhibitory protein
    MUK-binding inhibitory protein
    Mocs2B-PA
    molybdenum cofactor synthesis 2
    molybdopterin synthase 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25125632..25127359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143083.3NP_651340.1  molybdenum cofactor synthesis 2B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651340.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q961W4, Q9VBX2
      Related
      FBpp0084157
      Conserved Domains (1) summary
      cd00756
      Location:11137
      MoaE; MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...