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    mago mago nashi [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37402, updated on 9-Dec-2024

    Summary

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    Official Symbol
    magoprovided by FlyBase
    Official Full Name
    mago nashiprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002736
    Locus tag
    Dmel_CG9401
    See related
    AllianceGenome:FB:FBgn0002736
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9401; Dm MGN; Dmel\CG9401; DmMago; l(2)57Ca; Mago; MAGO; Magoh; MAGOH; mgn; MGN
    Summary
    Involved in several processes, including RNA splicing; oocyte microtubule cytoskeleton polarization; and regulation of pole plasm oskar mRNA localization. Located in nucleus and pole plasm. Part of exon-exon junction complex. Is expressed in several structures, including antennal anlage; embryonic/larval midgut primordium; female germline cell; ganglia; and head epidermis primordium. Orthologous to human MAGOHB (mago homolog B, exon junction complex subunit) and MAGOH (mago homolog, exon junction complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mago in Genome Data Viewer
    Location:
    57C2-57C2; 2-93 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21128577..21129737)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17016082..17017242)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene king tubby Neighboring gene uncharacterized protein Neighboring gene Transmembrane O-mannosyltransferase targeting cadherins 3 Neighboring gene magi Neighboring gene uncharacterized protein Neighboring gene X box binding protein-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in a newly identified Drosophila melanogaster gene, mago nashi, disrupt germ cell formation and result in the formation of mirror-image symmetrical double abdomen embryos. Boswell RE, et al. Development, 1991 Sep. PMID 1765008
    2. Crystal structure of the Drosophila Mago nashi-Y14 complex. Shi H, et al. Genes Dev, 2003 Apr 15. PMID 12704080, Free PMC Article
    3. The protein Mago provides a link between splicing and mRNA localization. Le Hir H, et al. EMBO Rep, 2001 Dec. PMID 11743026, Free PMC Article
    4. A novel mode of RBD-protein recognition in the Y14-Mago complex. Fribourg S, et al. Nat Struct Biol, 2003 Jun. PMID 12730685
    5. Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex. Bono F, et al. EMBO Rep, 2004 Mar. PMID 14968132, Free PMC Article

    See all (153) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MAPK is the primary functional target of mago in eye development; in cultured cells, Mago knockdown disproportionately affects other large genes located in heterochromatin
      Title: Exon junction complex subunits are required to splice Drosophila MAP kinase, a large heterochromatic gene.
    2. Mago Nashi, Tsunagi/Y14, and Ranshi form a complex that influences oocyte differentiation in Drosophila melanogaster
      Title: Mago Nashi, Tsunagi/Y14, and Ranshi form a complex that influences oocyte differentiation in Drosophila melanogaster.
    3. mago nashi is required for germline stem cell differentiation, but surprisingly mago nashi functions independently of tsunagi/Y14 in this process
      Title: Mago Nashi and Tsunagi/Y14, respectively, regulate Drosophila germline stem cell differentiation and oocyte specification.
    4. We have determined the crystal structure of the complex between Drosophila melanogaster Y14 and Mago at a resolution of 2.5 A. The structure reveals an atypical mode of protein-protein recognition mediated by an RNA-binding domain (RBD).
      Title: A novel mode of RBD-protein recognition in the Y14-Mago complex.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in maintenance of pole plasm mRNA location TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in oocyte microtubule cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in oocyte microtubule cytoskeleton polarization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pole plasm assembly TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in pole plasm oskar mRNA localization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in regulation of pole plasm oskar mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of exon-exon junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exon-exon junction complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of exon-exon junction complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in pole plasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    mago nashi
    Names
    CG9401-PA
    mago nishi
    mago-PA
    mago-nashi

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21128577..21129737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057288.4 → NP_476636.1  mago nashi [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476636.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P49028, Q9W2L3
      UniProtKB/TrEMBL
      A0A023T5E7
      Related
      FBpp0071497
      Conserved Domains (1) summary
      cd11295
      Location:5 → 147
      Mago_nashi; Mago nashi proteins, integral members of the exon junction complex
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49028.1 P49028

    Gene LinkOut

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