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    Cyp4d20 Cytochrome P450 4d20 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38311, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp4d20provided by FlyBase
    Official Full Name
    Cytochrome P450 4d20provided by FlyBase
    Primary source
    FLYBASE:FBgn0035344
    Locus tag
    Dmel_CG16761
    See related
    AllianceGenome:FB:FBgn0035344
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4d20; CG16761; CYP4d20; Dmel\CG16761; RH59895
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp4d20 in Genome Data Viewer
    Location:
    62E3-62E3; 3-3 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2476259..2478448, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2476259..2478448, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Supervillin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mitotic spindle organizing protein 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ran participates in deltamethrin stress through regulating the nuclear import of Nrf2. Ge M, et al. Gene, 2021 Feb 15. PMID 33069802
    2. Metabolic activation and toxicological evaluation of polychlorinated biphenyls in Drosophila melanogaster. Idda T, et al. Sci Rep, 2020 Dec 9. PMID 33299007, Free PMC Article
    3. Comparative CYP-omic analysis between the DDT-susceptible and -resistant Drosophila melanogaster strains 91-C and 91-R. Seong KM, et al. Pest Manag Sci, 2018 Nov. PMID 29656515
    4. dGLYAT modulates Gadd45-mediated JNK activation and cell invasion. Xu M, et al. Cell Div, 2022 Aug 6. PMID 35933447, Free PMC Article
    5. Cytochrome P450-dependent metabolism of caffeine in Drosophila melanogaster. Coelho A, et al. PLoS One, 2015. PMID 25671424, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 4d20
    Names
    CG16761-PA
    Cyp4d20-PA
    NP_647723.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      2476259..2478448 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139466.5 → NP_647723.2  cytochrome P450 4d20 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647723.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W011
      UniProtKB/TrEMBL
      H8F4S6, Q8SZ48
      Related
      FBpp0072837
      Conserved Domains (1) summary
      pfam00067
      Location:34 → 493
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZ48 Q8SZ48
    Q9W011.1 Q9W011

    Gene LinkOut

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