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    Syx7 Syntaxin 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36173, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Syx7provided by FlyBase
    Official Full Name
    Syntaxin 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0267849
    Locus tag
    Dmel_CG5081
    See related
    AllianceGenome:FB:FBgn0267849
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Aval; avl; Avl; braided; CG5081; Dm Syx7; Dmel\CG5081; DmSyx7; dSyn7; FCP-C; STX7; Syx; syx7; SYX7; syx7/avl
    Summary
    Predicted to enable SNAP receptor activity and SNARE binding activity. Involved in several processes, including endosomal vesicle fusion; negative regulation of imaginal disc growth; and pupariation. Located in early endosome. Is expressed in adult head; embryonic/larval hemocyte; and organism. Used to study cancer and carcinoma. Orthologous to several human genes including STX7 (syntaxin 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Syx7 in Genome Data Viewer
    Location:
    78D2-78D2; 3-47 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21445834..21448128)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21438934..21441228)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Adult enhancer factor 1 Neighboring gene uncharacterized protein Neighboring gene Alkaline phosphatase 1 Neighboring gene crocodile Neighboring gene Neuroectoderm-expressed 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Size matters! Aurora A controls Drosophila larval development. Vaufrey L, et al. Dev Biol, 2018 Aug 15. PMID 29753017
    2. Drosophila Insulin-Like Peptide 8 (DILP8) in Ovarian Follicle Cells Regulates Ovulation and Metabolism. Liao S, et al. Front Endocrinol (Lausanne), 2020. PMID 32849266, Free PMC Article
    3. Drosophila mauve mutants reveal a role of LYST homologs late in the maturation of phagosomes and autophagosomes. Rahman M, et al. Traffic, 2012 Dec. PMID 22934826, Free PMC Article
    4. The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking. Vaccari T, et al. Dev Cell, 2005 Nov. PMID 16256743
    5. Ribbon modulates apical membrane during tube elongation through Crumbs and Moesin. Kerman BE, et al. Dev Biol, 2008 Aug 1. PMID 18585700, Free PMC Article

    See all (119) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNARE binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endosomal vesicle fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of apical/basal cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of imaginal disc growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plasma membrane to endosome transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pupariation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    syntaxin 7
    Names
    CG5081-PA
    CG5081-PB
    Syntaxin7
    Syx7-PA
    Syx7-PB
    avalanche
    braided
    dSyntaxin-7
    synatxin7/avalanche
    syntaxin
    syntaxin-7

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21445834..21448128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168906.2 → NP_730633.1  syntaxin 7, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730633.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K0X9
      Related
      FBpp0078008
      Conserved Domains (3) summary
      COG5325
      Location:97 → 276
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      pfam14523
      Location:30 → 126
      Syntaxin_2; Syntaxin-like protein
      cl22856
      Location:188 → 247
      SNARE; SNARE motif

    2. NM_168905.2 → NP_730632.1  syntaxin 7, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730632.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K0X9
      Related
      FBpp0078007
      Conserved Domains (3) summary
      COG5325
      Location:97 → 276
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      pfam14523
      Location:30 → 126
      Syntaxin_2; Syntaxin-like protein
      cl22856
      Location:188 → 247
      SNARE; SNARE motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K0X9 Q7K0X9

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