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    CG10226 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38725, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10226provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035695
    Locus tag
    Dmel_CG10226
    See related
    AllianceGenome:FB:FBgn0035695
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AMT; DmCG10226; Dmel\CG10226
    Summary
    Predicted to enable ABC-type xenobiotic transporter activity and efflux transmembrane transporter activity. Involved in renal tubular secretion and response to toxic substance. Predicted to be located in plasma membrane. Predicted to be part of ATP-binding activity cassette (ABC) transporter complex. Predicted to be active in membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cholestasis (multiple); drug dependence (multiple); and human immunodeficiency virus infectious disease (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1); ABCB4 (ATP binding cassette subfamily B member 4); and ABCB5 (ATP binding cassette subfamily B member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10226 in Genome Data Viewer
    Location:
    65A10-65A10; 3-16 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6234323..6240068, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6227423..6233168, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene BG642312 Neighboring gene uncharacterized protein Neighboring gene Multi drug resistance 65 Neighboring gene Bestrophin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Physiological and molecular characterization of methotrexate transport by Malpighian tubules of adult Drosophila melanogaster. Chahine S, et al. J Insect Physiol, 2009 Oct. PMID 19545574
    2. Cellular and molecular organization of the Drosophila foregut. Zhu H, et al. Proc Natl Acad Sci U S A, 2024 Mar 12. PMID 38442150, Free PMC Article
    3. The genetic basis of incipient sexual isolation in Drosophila melanogaster. Yamamoto A, et al. Proc Biol Sci, 2024 Aug. PMID 39045689, Free PMC Article
    4. Characterization of a novel pesticide transporter and P-glycoprotein orthologues in Drosophila melanogaster. Denecke S, et al. Proc Biol Sci, 2022 May 25. PMID 35582794, Free PMC Article
    5. X chromosome-linked intellectual disability protein PQBP1 associates with and regulates the translation of specific mRNAs. Wan D, et al. Hum Mol Genet, 2015 Aug 15. PMID 26002102

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ABC-type xenobiotic transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables efflux transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in renal tubular secretion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    ABC multidrug transporter
    CG10226-PA
    CG10226-PB
    NP_001261473.1
    NP_648040.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6234323..6240068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139783.2 → NP_648040.1  uncharacterized protein Dmel_CG10226, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648040.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRW2
      Related
      FBpp0076720
      Conserved Domains (3) summary
      cd03249
      Location:414 → 649
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      PTZ00265
      Location:81 → 1311
      PTZ00265; multidrug resistance protein (mdr1); Provisional
      pfam00664
      Location:749 → 1019
      ABC_membrane; ABC transporter transmembrane region

    2. NM_001274544.1 → NP_001261473.1  uncharacterized protein Dmel_CG10226, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261473.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEB5
      Conserved Domains (3) summary
      cd03249
      Location:300 → 535
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      PTZ00265
      Location:39 → 1197
      PTZ00265; multidrug resistance protein (mdr1); Provisional
      pfam00664
      Location:635 → 905
      ABC_membrane; ABC transporter transmembrane region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PEB5 M9PEB5
    Q95SM0 Q95SM0
    Q9VRW2 Q9VRW2

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