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    TBC1D16 TBC1 domain family member 16 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34431, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TBC1D16provided by FlyBase
    Official Full Name
    TBC1 domain family member 16provided by FlyBase
    Primary source
    FLYBASE:FBgn0032249
    Locus tag
    Dmel_CG5337
    See related
    AllianceGenome:FB:FBgn0032249
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5337; Dmel\CG5337
    Summary
    Predicted to enable GTPase activator activity. Predicted to be active in early endosome. Orthologous to human TBC1D16 (TBC1 domain family member 16). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TBC1D16 in Genome Data Viewer
    Location:
    31E2-31E2; 2-42 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10432687..10435656, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10432687..10435656, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene KDEL receptor Neighboring gene uncharacterized protein Neighboring gene Basal body up regulated gene 22 Neighboring gene Transcription factor IIB Neighboring gene hole-in-one Neighboring gene STIP1 homology and U-box containing protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins. Gabernet-Castello C, et al. Mol Biol Cell, 2013 May. PMID 23485563, Free PMC Article
    2. Genome-Wide Analysis Reveals Novel Regulators of Growth in Drosophila melanogaster. Vonesch SC, et al. PLoS Genet, 2016 Jan. PMID 26751788, Free PMC Article
    3. Evi5 promotes collective cell migration through its Rab-GAP activity. Laflamme C, et al. J Cell Biol, 2012 Jul 9. PMID 22778279, Free PMC Article
    4. GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila. Bernards A. Biochim Biophys Acta, 2003 Mar 17. PMID 12618308
    5. Toward a comprehensive map of the effectors of rab GTPases. Gillingham AK, et al. Dev Cell, 2014 Nov 10. PMID 25453831, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TBC1 domain family member 16
    Names
    CG5337-PA
    TBC1D16-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10432687..10435656 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135559.3 → NP_609403.2  TBC1 domain family member 16 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609403.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SY79, Q9VKV6
      Related
      FBpp0079633
      Conserved Domains (1) summary
      smart00164
      Location:387 → 618
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SY79 Q8SY79
    Q9VKV6 Q9VKV6

    Gene LinkOut

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