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    E(spl)m6-BFM Enhancer of split m6, Bearded family member [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43159, updated on 17-Dec-2024

    Summary

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    Official Symbol
    E(spl)m6-BFMprovided by FlyBase
    Official Full Name
    Enhancer of split m6, Bearded family memberprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002632
    Locus tag
    Dmel_CG8354
    See related
    AllianceGenome:FB:FBgn0002632
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8354; DmelCG8354; Dmel\CG8354; E(spl)-m6; E(spl)m6; E(spl)M6; HLHm6; m6; M6
    Summary
    Enables ubiquitin protein ligase binding activity. Involved in cell fate specification; negative regulation of Notch signaling pathway; and sensory organ development. Is expressed in several structures, including embryonic/larval midgut; ganglia; myoblast; presumptive embryonic/larval system; and section of wing margin. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See E(spl)m6-BFM in Genome Data Viewer
    Location:
    96F10-96F10; 3-89 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26032911..26034047)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21858633..21859769)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Enhancer of split m4, Bearded family member Neighboring gene Enhancer of split m5, helix-loop-helix Neighboring gene Enhancer of split m7, helix-loop-helix Neighboring gene Enhancer of split m8, helix-loop-helix

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dual-Color Live Imaging of Adult Muscle Stem Cells in the Embryonic Tissues of Drosophila melanogaster. Zmojdzian M, et al. Bio Protoc, 2023 Feb 5. PMID 36816994, Free PMC Article
    2. Matrix metalloproteinases: Master regulators of tissue morphogenesis. Sreesada P, et al. Gene, 2025 Jan 15. PMID 39393432
    3. Two genetically and molecularly distinct functions involved in early neurogenesis reside within the Enhancer of split locus of Drosophila melanogaster. Delidakis C, et al. Genetics, 1991 Nov. PMID 1752423, Free PMC Article
    4. Closely related transcripts encoded by the neurogenic gene complex enhancer of split of Drosophila melanogaster. Klämbt C, et al. EMBO J, 1989 Jan. PMID 2540957, Free PMC Article
    5. A forward genetic screen in Drosophila implicates insulin signaling in age-related locomotor impairment. Jones MA, et al. Exp Gerontol, 2009 Aug. PMID 19481596, Free PMC Article

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    enhancer of split m6, bearded family member
    Names
    CG8354-PA
    E(spl) region transcript m6
    E(spl)m6-BFM-PA
    enhancer of split m6
    enhancer of split region transcript m6

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      26032911..26034047
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079788.3 → NP_524512.2  enhancer of split m6, bearded family member [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524512.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C9QP91, C9QPH4, O97179, Q5S4C4, Q5S4H2, Q5S4J6, Q9VBI7
      Related
      FBpp0084333
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O97179.2 O97179

    Gene LinkOut

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