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    dbo diablo [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53556, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dboprovided by FlyBase
    Official Full Name
    diabloprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040230
    Locus tag
    Dmel_CG6224
    See related
    AllianceGenome:FB:FBgn0040230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6224; Dbo; DIABLO; Dm.DBO; Dmel\CG6224; henji; Smac
    Summary
    Enables ubiquitin-like ligase-substrate adaptor activity. Involved in negative regulation of synaptic assembly at neuromuscular junction and proteasome-mediated ubiquitin-dependent protein catabolic process. Part of Cul3-RING ubiquitin ligase complex. Is expressed in several structures, including CNS glial cell; anlage in statu nascendi; antennal anlage; ganglia; and head epidermis primordium. Orthologous to human KLHL20 (kelch like family member 20). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dbo in Genome Data Viewer
    Location:
    72A2-72A2; 3-43 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15826888..15832004)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15819988..15825104)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene CKII-alpha subunit interactor-1 Neighboring gene Decapping protein 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism. Hawkins CJ, et al. Apoptosis, 2001 Oct. PMID 11483856
    2. The BACK domain in BTB-kelch proteins. Stogios PJ, et al. Trends Biochem Sci, 2004 Dec. PMID 15544948
    3. Drosophila veto puts a stop to cell survival. Holcik M. Trends Cell Biol, 2002 May. PMID 12062163
    4. Dbo/Henji Modulates Synaptic dPAK to Gate Glutamate Receptor Abundance and Postsynaptic Response. Wang M, et al. PLoS Genet, 2016 Oct. PMID 27736876, Free PMC Article
    5. Drosophila decapping protein 2 modulates the formation of cortical F-actin for germ plasm assembly. Lee YM, et al. Dev Biol, 2020 May 1. PMID 32007453

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    diablo
    Names
    CG6224-PA
    CG6224-PB
    DIABLO
    dDiablo
    dbo-PA
    dbo-PB
    henji

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15826888..15832004
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080250.3 → NP_524989.2  diablo, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524989.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NGX7, Q9VUU5
      Related
      FBpp0075260
      Conserved Domains (3) summary
      PHA03098
      Location:69 → 587
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:454 → 497
      Kelch; KELCH repeat [structural motif]
      cd18249
      Location:49 → 176
      BTB_POZ_KLHL20_KLEIP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20)

    2. NM_001274963.1 → NP_001261892.1  diablo, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261892.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFL3
      Conserved Domains (3) summary
      PHA03098
      Location:69 → 587
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:454 → 497
      Kelch; KELCH repeat [structural motif]
      cd18249
      Location:49 → 176
      BTB_POZ_KLHL20_KLEIP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFL3 M9PFL3
    Q9VUU5.1 Q9VUU5

    Gene LinkOut

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