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    CG15177 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40810, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG15177provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037461
    Locus tag
    Dmel_CG15177
    See related
    AllianceGenome:FB:FBgn0037461
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG15177
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in regulation of signal transduction. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human CLXN (calaxin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG15177 in Genome Data Viewer
    Location:
    84A1-84A1; 3-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6628204..6629321, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2453926..2455043, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene globin 2 Neighboring gene solwind Neighboring gene sungrazer Neighboring gene uncharacterized protein Neighboring gene Argininosuccinate synthase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The RNA export factor, Nxt1, is required for tissue specific transcriptional regulation. Caporilli S, et al. PLoS Genet, 2013 Jun. PMID 23754955, Free PMC Article
    2. Post-meiotic transcription in Drosophila testes. Barreau C, et al. Development, 2008 Jun. PMID 18434411
    3. Quantitative proteomics and phosphoproteomics reveal insights into mechanisms of ocnus function in Drosophila testis development. Zheng Y, et al. BMC Genomics, 2023 May 26. PMID 37237333, Free PMC Article
    4. Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster. Ni JQ, et al. Nat Methods, 2008 Jan. PMID 18084299, Free PMC Article
    5. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG15177-PA
    CG15177-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      6628204..6629321 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275394.1 → NP_001262323.1  uncharacterized protein Dmel_CG15177, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262323.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGA9
      Conserved Domains (2) summary
      pfam13499
      Location:115 → 172
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:116 → 171
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    2. NM_141415.2 → NP_649672.1  uncharacterized protein Dmel_CG15177, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649672.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VI39
      Related
      FBpp0081198
      Conserved Domains (2) summary
      pfam13499
      Location:115 → 180
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:116 → 179
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGA9 A0A0B4KGA9
    Q9VI39 Q9VI39

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