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    CG8952 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32525, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8952provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030688
    Locus tag
    Dmel_CG8952
    See related
    AllianceGenome:FB:FBgn0030688
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8952; SP52
    Summary
    Enables serine hydrolase activity. Predicted to be involved in innate immune response and proteolysis. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8952 in Genome Data Viewer
    Location:
    13E14-13E14; 1-51 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15765470..15766445, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15659503..15660478, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene GTPase regulator associated with FAK Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L3 Neighboring gene RNA polymerase III subunit A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Parent-of-origin effects on mRNA expression in Drosophila melanogaster not caused by genomic imprinting. Wittkopp PJ, et al. Genetics, 2006 Jul. PMID 16702434, Free PMC Article
    2. Control of metabolic adaptation to fasting by dILP6-induced insulin signaling in Drosophila oenocytes. Chatterjee D, et al. Proc Natl Acad Sci U S A, 2014 Dec 16. PMID 25472843, Free PMC Article
    3. Drosophila p53 directs nonapoptotic programs in postmitotic tissue. Kurtz P, et al. Mol Biol Cell, 2019 May 15. PMID 30892991, Free PMC Article
    4. Genes regulated by mating, sperm, or seminal proteins in mated female Drosophila melanogaster. McGraw LA, et al. Curr Biol, 2004 Aug 24. PMID 15324670
    5. Enhanced function annotations for Drosophila serine proteases: a case study for systematic annotation of multi-member gene families. Shah PK, et al. Gene, 2008 Jan 15. PMID 17996400

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8952-PA
    NP_573072.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15765470..15766445 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132844.3 → NP_573072.1  uncharacterized protein Dmel_CG8952 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573072.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K2R3, Q9VXP8
      Related
      FBpp0073978
      Conserved Domains (2) summary
      smart00020
      Location:37 → 268
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:38 → 271
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K2R3 Q7K2R3
    Q9VXP8 Q9VXP8

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