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    Usp12-46 Ubiquitin-specific protease 12/46 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42702, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Usp12-46provided by FlyBase
    Official Full Name
    Ubiquitin-specific protease 12/46provided by FlyBase
    Primary source
    FLYBASE:FBgn0039025
    Locus tag
    Dmel_CG7023
    See related
    AllianceGenome:FB:FBgn0039025
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7023; Dmel\CG7023; Q9VCT9; Usp12; Usp12/46
    Summary
    Enables deubiquitinase activity. Involved in negative regulation of Notch signaling pathway; negative regulation of ubiquitin-dependent protein catabolic process; and positive regulation of canonical Wnt signaling pathway. Part of peptidase complex. Is expressed in several structures, including embryonic/larval midgut interstitial cell; ganglia; gut section; and salivary gland body primordium. Orthologous to several human genes including USP12 (ubiquitin specific peptidase 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Usp12-46 in Genome Data Viewer
    Location:
    94C4-94C6; 3-76 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22750901..22776374)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18576623..18602096)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Heterochromatin Protein 1c Neighboring gene rumi Neighboring gene uncharacterized protein Neighboring gene Neprilysin-like 13 Neighboring gene Neprilysin-like 14 Neighboring gene Neprilysin-like 15 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43654 Neighboring gene mir-4953 stem loop Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease. Aron R, et al. Nat Commun, 2018 Sep 28. PMID 30266909, Free PMC Article
    2. The Deubiquitinating Enzyme UBPY Is Required for Lysosomal Biogenesis and Productive Autophagy in Drosophila. Jacomin AC, et al. PLoS One, 2015. PMID 26571504, Free PMC Article
    3. The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6. Spencer ZT, et al. Nat Commun, 2023 Oct 5. PMID 37798281, Free PMC Article
    4. The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation. Moretti J, et al. J Biol Chem, 2012 Aug 24. PMID 22778262, Free PMC Article
    5. Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. Acar M, et al. Cell, 2008 Jan 25. PMID 18243100, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of peptidase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ubiquitin-specific protease 12/46
    Names
    CG7023-PB
    Ubiquitin-specific protease 12/46 ortholog
    Usp12-46-PB
    NP_651099.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22750901..22776374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142842.3 → NP_651099.1  Ubiquitin-specific protease 12/46 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651099.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VCT9
      Related
      FBpp0083704
      Conserved Domains (1) summary
      cd02663
      Location:25 → 419
      Peptidase_C19G; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VCT9 Q9VCT9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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