pdm2 POU domain protein 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: pdm2provided by FlyBase
Official Full Name: POU domain protein 2provided by FlyBase
Primary source: FLYBASE:FBgn0004394
Locus tag: Dmel_CG12287
See related: AllianceGenome:FB:FBgn0004394
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12287; CG15486; CG15487; dim; Dmel\CG12287; dOct2; dPOU-28; dpou28; dPOU28; dPOU28/pdm-2; miti; Miti; Oct-2; Oct2; pdm; Pdm; pdm-2; Pdm-2; Pdm2
Summary: Enables DNA binding activity and DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including ectoderm development; nervous system development; and regulation of neural precursor cell proliferation. Located in nucleus. Is expressed in several structures, including compound sense organ; larval neurons; organism subdivision; sensory nervous system primordium; and somatic precursor cell. Orthologous to human POU2F1 (POU class 2 homeobox 1); POU2F2 (POU class 2 homeobox 2); and POU2F3 (POU class 2 homeobox 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 33F2-33F3; 2-47 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (12657165..12686306)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (12657165..12686306)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Temporal transcription factors determine circuit membership by permanently altering motor neuron-to-muscle synaptic partnerships.
Title: Temporal transcription factors determine circuit membership by permanently altering motor neuron-to-muscle synaptic partnerships.
Data identify pdm2 as a direct target gene that must be repressed to maintain neuroblast competence, but show that additional genes must also be repressed.
Title: Recombineering Hunchback identifies two conserved domains required to maintain neuroblast competence and specify early-born neuronal identity.
maintaining high levels of Mitimere or Nubbin, two POU proteins, in a ganglion mother cell causes it to undergo self-renewing asymmetric divisions
Title: Upregulation of Mitimere and Nubbin acts through cyclin E to confer self-renewing asymmetric division potential to neural precursor cells.
Pdm and Cas specify late-born neuronal identity; that Pdm and Cas act combinatorially to specify a temporal identity distinct from either protein alone, and that Cas repression of pdm expression regulates the generation of neuronal diversity.
Title: Pdm and Castor specify late-born motor neuron identity in the NB7-1 lineage.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ectoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in generation of neurons	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neural precursor cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: POU domain protein 2

Names: CG12287-PA; CG12287-PB; CG12287-PC; CG12287-PD; Miti-mere; POU domain prot 2; didymous; pdm2-PA; pdm2-PB; pdm2-PC; pdm2-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

12657165..12686306

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298949.1 → NP_001285878.1 POU domain protein 2, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285878.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q6NR25, Q9VK71

UniProtKB/TrEMBL

X2J9L4

Conserved Domains (2) summary

smart00352
Location:691 → 755

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:789 → 842

Homeobox; Homeobox domain
NM_001298948.1 → NP_001285877.1 POU domain protein 2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285877.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q6NR25, Q9VK71

UniProtKB/TrEMBL

X2J9L4

Conserved Domains (2) summary

smart00352
Location:691 → 755

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:789 → 842

Homeobox; Homeobox domain
NM_165017.2 → NP_723763.1 POU domain protein 2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723763.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q6NR25, Q9VK71

UniProtKB/TrEMBL

X2J9L4

Related

FBpp0079973

Conserved Domains (2) summary

smart00352
Location:691 → 755

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:789 → 842

Homeobox; Homeobox domain
NM_078834.3 → NP_523558.2 POU domain protein 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523558.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P31369, Q24430, Q6NR41, Q9VK70

UniProtKB/TrEMBL

C3KGP3, H0RNL2

Related

FBpp0079974

Conserved Domains (2) summary

smart00352
Location:296 → 360

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:394 → 447

Homeobox; Homeobox domain