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    GluRIA Glutamate receptor IA [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38742, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GluRIAprovided by FlyBase
    Official Full Name
    Glutamate receptor IAprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004619
    Locus tag
    Dmel_CG8442
    See related
    AllianceGenome:FB:FBgn0004619
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8442; DGluR-I; dglur-IA; DGluR-IA; dGluRI; DGluRI; DmelGlu-R1; Dmel\CG8442; Dro GluRIA; Glu-R1; Glu-RI; GluR1; GluR1A; GluRI; GluRIIA
    Summary
    Enables kainate selective glutamate receptor activity. Involved in monoatomic cation transport. Predicted to be located in membrane. Predicted to be part of ionotropic glutamate receptor complex. Predicted to be active in postsynaptic density membrane. Is expressed in several structures, including CNS glial cell; adult head; dorsal ectoderm anlage; ganglia; and larval midline neurons. Used to study central nervous system disease. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; autosomal recessive intellectual developmental disorder 76; epilepsy; schizophrenia; and syndromic X-linked intellectual disability 94. Orthologous to several human genes including GRIA2 (glutamate ionotropic receptor AMPA type subunit 2) and GRIA3 (glutamate ionotropic receptor AMPA type subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GluRIA in Genome Data Viewer
    Location:
    65C1-65C1; 3-17 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6624032..6635059)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6617132..6628159)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45418 Neighboring gene axundead Neighboring gene long non-coding RNA:CR45238 Neighboring gene long non-coding RNA:CR45239

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Study of the stereoselectivity of L-glutamate receptors by synthetic 4(R)- and 4(S)-substituted L-glutamate analogues. Chang YC, et al. Brain Res, 1993 Feb 26. PMID 8457866
    2. Glutamate receptors of Drosophila melanogaster: cloning of a kainate-selective subunit expressed in the central nervous system. Ultsch A, et al. Proc Natl Acad Sci U S A, 1992 Nov 1. PMID 1359540, Free PMC Article
    3. Molecular analysis of Drosophila glutamate receptors. Schuster CM, et al. EXS, 1993. PMID 7678526
    4. Amelioration of a neurodevelopmental disorder by carbamazepine in a case having a gain-of-function GRIA3 variant. Hamanaka K, et al. Hum Genet, 2022 Feb. PMID 35031858
    5. Molecular biology of ionotropic glutamate receptors in Drosophila melanogaster. Betz H, et al. Trends Pharmacol Sci, 1993 Dec. PMID 8122317

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kainate selective glutamate receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ionotropic glutamate receptor complex IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutamate receptor IA
    Names
    CG8442-PA
    GluRIA-PA
    glutamate receptor
    glutamate receptor I
    glutamate receptor kainate-selective subunit
    glutamate receptor subunit
    kainate receptor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6624032..6635059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057507.4 → NP_476855.1  glutamate receptor IA [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476855.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B6IDJ5, Q03445, Q86PC2, Q9VRX9
      Related
      FBpp0076691
      Conserved Domains (4) summary
      cd06380
      Location:41 → 453
      PBP1_iGluR_AMPA; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the AMPA receptor
      cd13715
      Location:477 → 879
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:612 → 907
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:53 → 434
      ANF_receptor; Receptor family ligand binding region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03445.2 Q03445

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