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    Polr1B RNA polymerase I subunit B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33210, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Polr1Bprovided by FlyBase
    Official Full Name
    RNA polymerase I subunit Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003278
    Locus tag
    Dmel_CG4033
    See related
    AllianceGenome:FB:FBgn0003278
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4033; Dmel\CG4033; DmRP135; l(2)k16513; RP135; RPA135; RpI135; RPI135; RpIII135; Rpl135
    Summary
    Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and ribonucleoside binding activity. Predicted to contribute to RNA polymerase I activity. Predicted to be involved in transcription by RNA polymerase I. Predicted to be located in nucleus. Predicted to be part of RNA polymerase I complex. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; gut section; and mesoderm. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 4. Orthologous to human POLR1B (RNA polymerase I subunit B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Polr1B in Genome Data Viewer
    Location:
    21C2-21C2; 2-0.7 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (404285..407969)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (404285..407969)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43718 Neighboring gene uncharacterized protein Neighboring gene Adaptor Protein complex 2, alpha subunit Neighboring gene ebi Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Primary structure and functional aspects of the gene coding for the second-largest subunit of RNA polymerase III of Drosophila. Kontermann R, et al. Mol Gen Genet, 1989 Nov. PMID 2482932
    2. Similarity between subunit 8 of yeast RNA polymerase II (RPB8) and the second-largest subunits of eukaryotic RNA polymerases. Kontermann R, et al. Nucleic Acids Res, 1992 Oct 11. PMID 1408842, Free PMC Article
    3. Identification of the genes coding for the second-largest subunits of RNA polymerases I and III of Drosophila melanogaster. Seifarth W, et al. Mol Gen Genet, 1991 Sep. PMID 1910149
    4. Nucleic acid-binding regions of the second-largest subunit of Drosophila RNA polymerase II identified by southwestern blotting. Kontermann RE, et al. FEBS Lett, 1994 May 16. PMID 8187877
    5. Nucleation by rRNA Dictates the Precision of Nucleolus Assembly. Falahati H, et al. Curr Biol, 2016 Feb 8. PMID 26776729, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase I activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribonucleoside binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase I complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA polymerase I subunit B
    Names
    CG4033-PA
    Polr1B-PA
    RNA polymerase I
    RNA polymerase I 135kD subunit
    NP_476708.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      404285..407969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057360.4 → NP_476708.1  RNA polymerase I subunit B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476708.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P20028, Q9VPP3
      Related
      FBpp0077714
      Conserved Domains (3) summary
      COG0085
      Location:34 → 1128
      RpoB; DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]
      cd00653
      Location:35 → 1125
      RNA_pol_B_RPB2; RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase ...
      pfam06883
      Location:564 → 614
      RNA_pol_Rpa2_4; RNA polymerase I, Rpa2 specific domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20028.2 P20028

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