disp dispatched [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: dispprovided by FlyBase
Official Full Name: dispatchedprovided by FlyBase
Primary source: FLYBASE:FBgn0029088
Locus tag: Dmel_CG2019
See related: AllianceGenome:FB:FBgn0029088
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0146227.1; CG2019; Disp; Dmel\CG2019
Summary: Involved in germ cell migration; patched ligand maturation; and regionalization. Located in cytoneme. Is expressed in adult head; imaginal disc; organism; and wing disc. Orthologous to human DISP1 (dispatched RND transporter family member 1) and DISP2 (dispatched RND transporter family member 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (5849697..5856311, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (1675419..1682033, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Data show that Dispatched could be involved in the regulation of vesicular trafficking necessary for basolateral release of Hh, Dlp, and Ihog.
Title: Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium.
dispatched plays a role in hedgehog body patterning, as demonstrated in transgenic flies
Title: Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in germ cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in patched ligand maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in patched ligand maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in segment polarity determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smoothened signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in wing disc pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoneme	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed

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