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    Daxx Daxx-like protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33906, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Daxxprovided by FlyBase
    Official Full Name
    Daxx-like proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031820
    Locus tag
    Dmel_CG9537
    See related
    AllianceGenome:FB:FBgn0031820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9537; DAXX; dlp; DLP; Dmel\CG9537
    Summary
    Predicted to enable transcription coregulator activity. Involved in several processes, including determination of adult lifespan; positive regulation of DNA-templated transcription; and response to oxidative stress. Located in cytosol and nucleus. Is expressed in larval brain; organism; and wing disc. Human ortholog(s) of this gene implicated in appendiceal neoplasm; islet cell tumor; oral squamous cell carcinoma; ovary epithelial cancer; and pancreatic endocrine carcinoma. Orthologous to human DAXX (death domain associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Daxx in Genome Data Viewer
    Location:
    26D8-26D9; 2-20 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6480929..6487576)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6480929..6487576)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Sec61 alpha subunit Neighboring gene long non-coding RNA:CR45463 Neighboring gene Kynurenine formamidase Neighboring gene Coat Protein (coatomer) epsilon Neighboring gene PHD finger protein 5a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of two independent SUMO-interacting motifs in Daxx: evolutionary conservation from Drosophila to humans and their biochemical functions. Santiago A, et al. Cell Cycle, 2009 Jan 1. PMID 19106612
    2. Modification of Drosophila p53 by SUMO modulates its transactivation and pro-apoptotic functions. Mauri F, et al. J Biol Chem, 2008 Jul 25. PMID 18492669, Free PMC Article
    3. Daxx-like protein of Drosophila interacts with Dmp53 and affects longevity and Ark mRNA level. Bodai L, et al. J Biol Chem, 2007 Dec 14. PMID 17933869
    4. Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response. Yang Y, et al. Nat Commun, 2019 Aug 21. PMID 31434890, Free PMC Article
    5. Genome-wide characterization of chromatin binding and nucleosome spacing activity of the nucleosome remodelling ATPase ISWI. Sala A, et al. EMBO J, 2011 May 4. PMID 21448136, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DJ-1beta protects flies against oxidative stress- and UV-induced apoptosis by regulating the subcellular localization and gene expression of DLP, thus implying that Daxx-induced apoptosis is involved in the pathogenesis of DJ-1-associated PD.
      Title: Drosophila DJ-1 decreases neural sensitivity to stress by negatively regulating Daxx-like protein through dFOXO.
    2. These results suggest that the conserved SUMO-interacting motifs are involved in mediating protein-protein interactions that underlie Daxx's diverse cellular functions.
      Title: Identification of two independent SUMO-interacting motifs in Daxx: evolutionary conservation from Drosophila to humans and their biochemical functions.
    3. Daxx-like protein of Drosophila interacts with Dmp53 and affects longevity and Ark mRNA level
      Title: Daxx-like protein of Drosophila interacts with Dmp53 and affects longevity and Ark mRNA level.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Daxx-like protein
    Names
    CG9537-PA
    CG9537-PB
    Daxx-PA
    Daxx-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6480929..6487576
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135191.3 → NP_609035.2  Daxx-like protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609035.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NNF9, Q9VMD0
      UniProtKB/TrEMBL
      Q8WSS9
      Related
      FBpp0078890
      Conserved Domains (3) summary
      PTZ00449
      Location:278 → 379
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PRK10263
      Location:707 → 892
      PRK10263; DNA translocase FtsK; Provisional
      cd13150
      Location:1276 → 1462
      DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)

    2. NM_001298746.1 → NP_001285675.1  Daxx-like protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285675.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NNF9, Q9VMD0
      UniProtKB/TrEMBL
      Q8WSS9
      Conserved Domains (3) summary
      PTZ00449
      Location:278 → 379
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PRK10263
      Location:707 → 892
      PRK10263; DNA translocase FtsK; Provisional
      cd13150
      Location:1276 → 1462
      DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5UDQ8 Q5UDQ8
    Q8WSS9 Q8WSS9
    Q95TR4 Q95TR4
    Q960X2 Q960X2
    Q9VMD0.3 Q9VMD0

    Gene LinkOut

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