Trp1 Translocation protein 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Trp1provided by FlyBase
Official Full Name: Translocation protein 1provided by FlyBase
Primary source: FLYBASE:FBgn0011584
Locus tag: Dmel_CG4758
See related: AllianceGenome:FB:FBgn0011584
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4758; Dmel\CG4758; Dtrp1; sec62; Tp1
Summary: Enables endoplasmic reticulum-autophagosome adaptor activity and protein transmembrane transporter activity. Involved in post-translational protein targeting to membrane, translocation and reticulophagy. Located in endomembrane system. Part of Sec62/Sec63 complex. Is active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; adult heart; ejaculatory duct; gonad; and male accessory gland. Orthologous to human SEC62 (SEC62 homolog, preprotein translocation factor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10009381..10013170)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10009381..10013170)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables endoplasmic reticulum-autophagosome adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in post-translational protein targeting to membrane, translocation	IBA Inferred from Biological aspect of Ancestor more info
involved_in post-translational protein targeting to membrane, translocation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in post-translational protein targeting to membrane, translocation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in reticulophagy	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Sec62/Sec63 complex	IGI Inferred from Genetic Interaction more info	PubMed
located_in endomembrane system	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum membrane	IC Inferred by Curator more info	PubMed
is_active_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

Names: CG4758-PA; CG4758-PB; CG4758-PC; CG4758-PD; Trp1-PA; Trp1-PB; Trp1-PC; Trp1-PD

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