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    Mipp1 Multiple inositol polyphosphate phosphatase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39841, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mipp1provided by FlyBase
    Official Full Name
    Multiple inositol polyphosphate phosphatase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0026061
    Locus tag
    Dmel_CG4123
    See related
    AllianceGenome:FB:FBgn0026061
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4123; CK2082; Dmel\CG4123; mipp1
    Summary
    Enables inositol phosphate phosphatase activity. Involved in open tracheal system development and positive regulation of filopodium assembly. Located in external side of plasma membrane and filopodium. Is expressed in several structures, including adult head; adult heart; embryonic/larval tracheal section; gut section; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in papillary thyroid carcinoma and pontocerebellar hypoplasia type 16. Orthologous to human MINPP1 (multiple inositol-polyphosphate phosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mipp1 in Genome Data Viewer
    Location:
    73A7-73A9; 3-44 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16563448..16573334, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16556548..16566434, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ubiquinol-cytochrome c reductase 6.4 kDa subunit-like Neighboring gene multiprotein bridging factor 1 Neighboring gene nuclear RNA export factor 2 Neighboring gene survival motor neuron

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extracellular Mipp1 Activity Confers Migratory Advantage to Epithelial Cells during Collective Migration. Cheng YL, et al. Cell Rep, 2015 Dec 15. PMID 26628373, Free PMC Article
    2. Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19. Chi H, et al. Genomics, 1999 Mar 15. PMID 10087200
    3. Tracheal development in Drosophila melanogaster as a model system for studying the development of a branched organ. Ebner A, et al. Gene, 2002 Apr 3. PMID 11992723
    4. Comparative transcriptional profiling identifies takeout as a gene that regulates life span. Bauer J, et al. Aging (Albany NY), 2010 May. PMID 20519778, Free PMC Article
    5. A phosphate-sensing organelle regulates phosphate and tissue homeostasis. Xu C, et al. Nature, 2023 May. PMID 37138087, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mipp1 facilitates formation and/or stabilization of filopodia in leading cells through its extracellular activity
      Title: Extracellular Mipp1 Activity Confers Migratory Advantage to Epithelial Cells during Collective Migration.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acid phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bisphosphoglycerate 3-phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables inositol phosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol phosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular exosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    multiple inositol polyphosphate phosphatase 1
    Names
    CG4123-PA
    CG4123-PB
    CG4123-PC
    Mipp1-PA
    Mipp1-PB
    Mipp1-PC
    NP_001287082.1
    NP_524109.2
    NP_730177.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16563448..16573334 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300153.1 → NP_001287082.1  multiple inositol polyphosphate phosphatase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287082.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96421, Q8SYN4, Q8T3I2, Q9VV72
      Conserved Domains (1) summary
      cd07061
      Location:129 → 402
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

    2. NM_168672.3 → NP_730177.1  multiple inositol polyphosphate phosphatase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730177.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96421, Q8SYN4, Q8T3I2, Q9VV72
      Related
      FBpp0075156
      Conserved Domains (1) summary
      cd07061
      Location:129 → 402
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

    3. NM_079385.4 → NP_524109.2  multiple inositol polyphosphate phosphatase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524109.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96421, Q8SYN4, Q8T3I2, Q9VV72
      Related
      FBpp0075157
      Conserved Domains (1) summary
      cd07061
      Location:129 → 402
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VV72.2 Q9VV72

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