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    ebd2 earthbound 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40363, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ebd2provided by FlyBase
    Official Full Name
    earthbound 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0037076
    Locus tag
    Dmel_CG12972
    See related
    AllianceGenome:FB:FBgn0037076
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12972; Dmel\CG12972
    Summary
    Predicted to enable DNA binding activity. Involved in adult somatic muscle development. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ebd2 in Genome Data Viewer
    Location:
    78C8-78C8; 3-47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21344768..21349288, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21337868..21342388, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Rab26 Neighboring gene antisense RNA:CR46068 Neighboring gene Tsr1 ribosome assembly factor Neighboring gene TBC1 domain family member 8/9 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating β-catenin-TCF activity. Benchabane H, et al. EMBO J, 2011 Apr 20. PMID 21399610, Free PMC Article
    2. Reduced histone gene copy number disrupts Drosophila Polycomb function. McPherson JE, et al. Genetics, 2023 Aug 9. PMID 37279945, Free PMC Article
    3. Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing. Tian A, et al. PLoS Genet, 2017 Jul. PMID 28708826, Free PMC Article
    4. Inter-Species Rescue of Mutant Phenotype-The Standard for Genetic Analysis of Human Genetic Disorders in Drosophila melanogaster Model. Ecovoiu AA, et al. Int J Mol Sci, 2022 Feb 27. PMID 35269756, Free PMC Article
    5. The Landscape of the DNA Transposons in the Genome of the Horezu_LaPeri Strain of Drosophila melanogaster. Bologa AM, et al. Insects, 2023 May 25. PMID 37367310, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adult somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    earthbound 2
    Names
    CG12972-PA
    CG12972-PB
    ebd2-PA
    ebd2-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21344768..21349288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259936.1 → NP_001246865.1  earthbound 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246865.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VP44
      Conserved Domains (2) summary
      smart00674
      Location:101 → 166
      CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
      pfam04218
      Location:27 → 80
      CENP-B_N; CENP-B N-terminal DNA-binding domain

    2. NM_141050.3 → NP_649307.1  earthbound 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649307.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VP44
      Related
      FBpp0078057
      Conserved Domains (2) summary
      smart00674
      Location:101 → 166
      CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
      pfam04218
      Location:27 → 80
      CENP-B_N; CENP-B N-terminal DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VP44 Q9VP44

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