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    Samuel SAM-motif ubiquitously expressed punctatedly localized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34530, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Samuelprovided by FlyBase
    Official Full Name
    SAM-motif ubiquitously expressed punctatedly localized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032330
    Locus tag
    Dmel_CG31868
    See related
    AllianceGenome:FB:FBgn0032330
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    78BP; CG12291; CG14917; CG14918; CG31868; Dmel\CG31868; mdcds_1002; moses; Moses
    Summary
    Predicted to enable chromatin binding activity and histone binding activity. Involved in regulation of growth. Predicted to be part of PRC1 complex. Predicted to be active in nucleus. Is expressed in adult tracheal system. Human ortholog(s) of this gene implicated in macular degeneration. Orthologous to human SAMD11 (sterile alpha motif domain containing 11) and SAMD7 (sterile alpha motif domain containing 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Samuel in Genome Data Viewer
    Location:
    32C1-32D1; 2-44 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11013206..11066998, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11013206..11066998, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45778 Neighboring gene Nucleoporin 154kD Neighboring gene Deoxyuridine triphosphatase Neighboring gene Arginine methyltransferase 8 Neighboring gene Accessory gland protein 32CD Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46264 Neighboring gene long non-coding RNA:CR45725 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional interactions between the Moses corepressor and DHR78 nuclear receptor regulate growth in Drosophila. Baker KD, et al. Genes Dev, 2007 Feb 15. PMID 17322404, Free PMC Article
    2. Requirement for sex comb on midleg protein interactions in Drosophila polycomb group repression. Peterson AJ, et al. Genetics, 2004 Jul. PMID 15280237, Free PMC Article
    3. Perturbation analysis of heterochromatin-mediated gene silencing and somatic inheritance. Schneiderman JI, et al. PLoS Genet, 2010 Sep 9. PMID 20838586, Free PMC Article
    4. Single-nucleus RNA-sequencing in pre-cellularization Drosophila melanogaster embryos. Albright AR, et al. PLoS One, 2022. PMID 35749552, Free PMC Article
    5. Comparative genomics of accessory gland protein genes in Drosophila melanogaster and D. pseudoobscura. Wagstaff BJ, et al. Mol Biol Evol, 2005 Apr. PMID 15601888

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DHR78 and Moses proteins are coexpressed during development and colocalize to specific genomic targets in chromatin.
      Title: Functional interactions between the Moses corepressor and DHR78 nuclear receptor regulate growth in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of PRC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SAM-motif ubiquitously expressed punctatedly localized protein
    Names
    CG31868-PA
    CG31868-PB
    CG31868-PD
    CG31868-PE
    Samuel-PA
    Samuel-PB
    Samuel-PD
    Samuel-PE
    middleman of seventy-eight signaling

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11013206..11066998 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080362.4 → NP_525101.2  SAM-motif ubiquitously expressed punctatedly localized protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525101.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0MSJ4, Q9VKL0
      Related
      FBpp0079750
      Conserved Domains (2) summary
      cd09579
      Location:795 → 862
      SAM_Samd7,11; SAM domain of Samd7,11 subfamily of Polycomb group
      smart00454
      Location:795 → 852
      SAM; Sterile alpha motif

    2. NM_001273443.3 → NP_001260372.1  SAM-motif ubiquitously expressed punctatedly localized protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260372.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0MSJ4, Q9VKL0
      Conserved Domains (2) summary
      cd09579
      Location:795 → 862
      SAM_Samd7,11; SAM domain of Samd7,11 subfamily of Polycomb group
      smart00454
      Location:795 → 852
      SAM; Sterile alpha motif

    3. NM_001298899.1 → NP_001285828.1  SAM-motif ubiquitously expressed punctatedly localized protein, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285828.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0MSJ4, M9PB98, X2JA41
      Conserved Domains (1) summary
      cl15755
      Location:795 → 823
      SAM_superfamily; SAM (Sterile alpha motif )

    4. NM_001273444.3 → NP_001260373.2  SAM-motif ubiquitously expressed punctatedly localized protein, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0MSJ4, M9PB98, X2JA41
      Conserved Domains (1) summary
      cl15755
      Location:795 → 823
      SAM_superfamily; SAM (Sterile alpha motif )
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0MSJ4 A0MSJ4
    M9PB98 M9PB98
    Q9VKL0 Q9VKL0

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